Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 86157..86800 Replicon plasmid pECO-6357
Accession NZ_CP026404
Organism Escherichia coli strain ECONIH4

Toxin (Protein)


Gene name vagD Uniprot ID D7Y5A6
Locus tag C3F40_RS29680 Protein ID WP_001044765.1
Coordinates 86384..86800 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag C3F40_RS29675 Protein ID WP_001261282.1
Coordinates 86157..86387 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F40_RS29645 81670..81936 - 267 WP_024144810.1 type II toxin-antitoxin system ParD family antitoxin -
C3F40_RS29650 82167..83840 - 1674 WP_000026497.1 hypothetical protein -
C3F40_RS29660 84405..85214 - 810 WP_000654269.1 hypothetical protein -
C3F40_RS29665 85232..85594 - 363 WP_000533745.1 hypothetical protein -
C3F40_RS31635 85778..86200 - 423 WP_162534719.1 hypothetical protein -
C3F40_RS29675 86157..86387 + 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C3F40_RS29680 86384..86800 + 417 WP_001044765.1 type II toxin-antitoxin system VapC family toxin Toxin
C3F40_RS29685 86874..88436 + 1563 WP_001128475.1 AAA family ATPase -
C3F40_RS29690 88421..89443 + 1023 WP_000361404.1 helicase UvrD -
C3F40_RS29700 90372..90593 + 222 Protein_88 IS5/IS1182 family transposase -
C3F40_RS29710 90742..91059 - 318 Protein_89 hypothetical protein -
C3F40_RS29715 91056..91541 - 486 WP_000045622.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..127217 127217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15148.60 Da        Isoelectric Point: 7.1082

>T94834 WP_001044765.1 NZ_CP026404:86384-86800 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLELAVLRGQRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPDLVLEDWVR

Download         Length: 417 bp

>T94834 NZ_CP026404:86384-86800 [Escherichia coli]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTGCCGGATCTGGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT94834 WP_001261282.1 NZ_CP026404:86157-86387 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT94834 NZ_CP026404:86157-86387 [Escherichia coli]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H9AY90

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References