Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 59156..59727 Replicon plasmid pECO-6357
Accession NZ_CP026404
Organism Escherichia coli strain ECONIH4

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag C3F40_RS29535 Protein ID WP_011918375.1
Coordinates 59416..59727 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag C3F40_RS29530 Protein ID WP_011787805.1
Coordinates 59156..59416 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F40_RS29500 54830..55111 - 282 WP_000780222.1 helix-turn-helix transcriptional regulator -
C3F40_RS29505 55092..55421 - 330 WP_000493286.1 type II toxin-antitoxin system RelE/ParE family toxin -
C3F40_RS29515 56118..57500 - 1383 WP_000426307.1 diguanylate cyclase -
C3F40_RS29520 57699..58169 - 471 Protein_59 IS6-like element IS26 family transposase -
C3F40_RS29525 58224..58928 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
C3F40_RS29530 59156..59416 + 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C3F40_RS29535 59416..59727 + 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C3F40_RS29540 59751..62831 + 3081 WP_011787830.1 Tn3 family transposase -
C3F40_RS31395 63005..63262 + 258 WP_000557619.1 type II toxin-antitoxin system antitoxin PemI -
C3F40_RS29545 63195..63596 + 402 WP_001398199.1 type II toxin-antitoxin system toxin endoribonuclease PemK -
C3F40_RS29555 63910..64607 + 698 Protein_66 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..127217 127217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T94833 WP_011918375.1 NZ_CP026404:59416-59727 [Escherichia coli]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T94833 NZ_CP026404:59416-59727 [Escherichia coli]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT94833 WP_011787805.1 NZ_CP026404:59156-59416 [Escherichia coli]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT94833 NZ_CP026404:59156-59416 [Escherichia coli]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References