Detailed information of TA system TA094818

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yafW/CbtA-CbeA
• Location: 4067102..4067802
• Replicon: chromosome
• Accession: NZ_CP026399
• Organism: Escherichia coli strain ECONIH4

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: C3F40_RS21615
• Protein ID: WP_016240265.1
• Coordinates: 4067102..4067386 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: yafW
• Uniprot ID: A0A794RE17
• Locus tag: C3F40_RS21620
• Protein ID: WP_016240264.1
• Coordinates: 4067476..4067802 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3F40_RS21600	4062675..4064357	+	1683	WP_104457551.1	glycolate permease GlcA	-
C3F40_RS21610	4064842..4067139	+	2298	Protein_3956	DUF4092 domain-containing protein	-
C3F40_RS21615	4067102..4067386	-	285	WP_016240265.1	TA system toxin CbtA family protein	Toxin
C3F40_RS21620	4067476..4067802	-	327	WP_016240264.1	type IV toxin-antitoxin system antitoxin YafW	Antitoxin
C3F40_RS21625	4067821..4068042	-	222	WP_016239820.1	DUF987 domain-containing protein	-
C3F40_RS21630	4068051..4068527	-	477	WP_016243826.1	RadC family protein	-
C3F40_RS21635	4068543..4069001	-	459	WP_000211838.1	antirestriction protein	-
C3F40_RS21640	4069099..4069338	-	240	WP_000194654.1	DUF905 domain-containing protein	-
C3F40_RS21645	4069433..4070137	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-
C3F40_RS21650	4070128..4071090	+	963	WP_104457552.1	hypothetical protein	-
C3F40_RS21655	4071135..4072322	-	1188	WP_104457553.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4069433..4070137	704

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-84)

Antitoxin

• Antitoxin CbeA (6-103)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10591.11 Da
• Isoelectric Point: 5.0063

>T94818 WP_016240265.1 NZ_CP026399:c4067386-4067102 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTLADRYLLPTC

Nucleotide

• Length: 285 bp

>T94818 NZ_CP026399:c4067386-4067102 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCTTGCGGATCGTTATTTACTACCGACTTGTTAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12332.00 Da
• Isoelectric Point: 7.0273

>AT94818 WP_016240264.1 NZ_CP026399:c4067802-4067476 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRTSITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 327 bp

>AT94818 NZ_CP026399:c4067802-4067476 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGACCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCTTCGGCTCCTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAA
AAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A794RE17