Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 33699..34530 Replicon chromosome
Accession NZ_CP026399
Organism Escherichia coli strain ECONIH4

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag C3F40_RS00250 Protein ID WP_000854814.1
Coordinates 33699..34073 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag C3F40_RS00255 Protein ID WP_001285585.1
Coordinates 34162..34530 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F40_RS00215 29095..30261 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
C3F40_RS00220 30380..30853 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
C3F40_RS00225 31051..32109 + 1059 WP_001200891.1 FUSC family protein -
C3F40_RS00230 32281..32610 + 330 WP_000450409.1 DUF496 family protein -
C3F40_RS00235 32711..32893 - 183 WP_001016348.1 hypothetical protein -
C3F40_RS00240 32965..33093 + 129 Protein_44 transposase domain-containing protein -
C3F40_RS31425 33382..33495 - 114 WP_032154230.1 DUF957 domain-containing protein -
C3F40_RS00245 33508..33702 - 195 WP_000988600.1 hypothetical protein -
C3F40_RS00250 33699..34073 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
C3F40_RS00255 34162..34530 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
C3F40_RS00260 34604..34825 - 222 WP_000692323.1 DUF987 domain-containing protein -
C3F40_RS00265 34888..35364 - 477 WP_001186773.1 RadC family protein -
C3F40_RS00270 35380..35859 - 480 WP_000860076.1 antirestriction protein -
C3F40_RS00275 35941..36759 - 819 WP_001234629.1 DUF945 domain-containing protein -
C3F40_RS00285 36859..37092 - 234 WP_001119729.1 DUF905 family protein -
C3F40_RS00290 37171..37626 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T94796 WP_000854814.1 NZ_CP026399:c34073-33699 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T94796 NZ_CP026399:c34073-33699 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT94796 WP_001285585.1 NZ_CP026399:c34530-34162 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT94796 NZ_CP026399:c34530-34162 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References