Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 221520..223146 Replicon plasmid pKPN-edaa
Accession NZ_CP026398
Organism Klebsiella pneumoniae strain KPNIH48

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C3F39_RS32590 Protein ID WP_103214914.1
Coordinates 221520..222845 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C3F39_RS32595 Protein ID WP_103214936.1
Coordinates 222850..223146 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F39_RS32570 217823..218200 + 378 WP_004181901.1 hypothetical protein -
C3F39_RS34315 218398..219372 - 975 WP_064794367.1 hypothetical protein -
C3F39_RS32580 219975..220133 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
C3F39_RS32585 220205..221356 + 1152 WP_104457672.1 IS481-like element ISKpn28 family transposase -
C3F39_RS32590 221520..222845 - 1326 WP_103214914.1 type II toxin-antitoxin system HipA family toxin Toxin
C3F39_RS32595 222850..223146 - 297 WP_103214936.1 helix-turn-helix transcriptional regulator Antitoxin
C3F39_RS32600 223455..223820 + 366 WP_103214915.1 hypothetical protein -
C3F39_RS32605 223864..224601 + 738 WP_103214916.1 HupE/UreJ family protein -
C3F39_RS32610 224615..225304 + 690 WP_103214917.1 transmembrane anchor protein -
C3F39_RS32615 225445..225816 + 372 WP_103214918.1 hypothetical protein -
C3F39_RS32620 225880..226800 + 921 WP_103214919.1 hypothetical protein -
C3F39_RS32625 226854..227612 + 759 WP_103214920.1 Tat pathway signal sequence -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..249238 249238
- flank IS/Tn - - 220205..221356 1151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-68)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50417.59 Da        Isoelectric Point: 6.2389

>T94795 WP_103214914.1 NZ_CP026398:c222845-221520 [Klebsiella pneumoniae]
MVRKQQRLAIWMNGIQVGFWEKSKGDDSLRYLPEWVADEQGRPLSLSLPFTPGNQILHGNVVRDYFDNLLPDSEGIRRRL
AMRYQADSLEPFDLLKELGKDCVGAIQLLSDEEEPTDLYSVKYRPLSESEIASTLRNTTEALLPGRHVDNDDLRLSIAGA
QEKTALLWHDGSWCLPLGHTPTTHIFKLPLGLVGNMKADMSTSVENEWLCSLLLEQYGVPVAKTRIAQFEDQKALVVERF
DRRWSGDQQWIIRLPQEDMCQALAVSPLRKYQADGGPGISDIMGVLSHSDRAEHDRIQFFRAQILFWLMAATDGHAKNFS
IAIEPRGQYHLTPLYDVLSAWPIIGNGNAQISWQKCKLAMAIRGSSNYYQIYRILRRHWIKHGEMTGLSRQQIEMMIDDI
VTVTPEVIERVYAQLPAHFPQELAESVFDGMRQQCRRLSEK

Download         Length: 1326 bp

>T94795 NZ_CP026398:c222845-221520 [Klebsiella pneumoniae]
ATGGTCAGGAAACAGCAACGTTTAGCGATATGGATGAACGGCATTCAGGTCGGGTTCTGGGAAAAGAGTAAAGGCGATGA
TTCGTTACGCTATCTCCCTGAATGGGTTGCTGACGAACAAGGTCGGCCATTGTCTCTGTCCCTGCCTTTCACACCCGGCA
ACCAAATTTTGCACGGTAACGTAGTACGTGATTATTTTGATAATTTACTGCCGGATAGTGAAGGGATCCGCAGGCGTCTG
GCAATGCGCTATCAGGCAGACAGTCTCGAACCTTTCGACTTGTTGAAAGAGTTGGGAAAAGACTGCGTGGGGGCAATACA
GCTACTGAGTGATGAAGAGGAACCCACTGATTTATATTCAGTAAAATATCGTCCTCTTTCTGAATCAGAAATCGCGTCAA
CATTACGAAATACGACGGAAGCGTTACTACCCGGCAGGCATGTCGATAATGATGACTTACGATTATCGATTGCCGGTGCG
CAGGAAAAAACAGCTTTACTGTGGCATGACGGCAGTTGGTGTCTGCCTCTGGGTCATACACCGACGACTCATATTTTCAA
GTTACCGCTCGGGCTGGTCGGGAATATGAAAGCAGATATGAGTACGTCAGTAGAAAATGAATGGCTCTGTTCGCTGCTTC
TTGAGCAATACGGGGTCCCTGTCGCCAAAACCCGGATTGCTCAATTTGAAGATCAGAAGGCTCTGGTGGTGGAACGTTTT
GATCGAAGATGGTCGGGAGACCAGCAGTGGATCATTCGCTTACCCCAGGAGGATATGTGCCAGGCTCTCGCGGTATCACC
ATTACGGAAATACCAGGCCGATGGCGGACCAGGGATCTCTGACATTATGGGTGTTCTGAGTCATTCAGACCGGGCTGAAC
ATGACAGAATACAGTTCTTCAGGGCTCAGATTCTTTTCTGGCTTATGGCCGCTACAGATGGCCACGCCAAAAATTTCAGT
ATCGCGATAGAGCCTCGCGGGCAGTATCATCTTACTCCGCTCTATGATGTTTTATCGGCATGGCCAATTATTGGCAACGG
AAATGCACAGATTTCCTGGCAGAAATGCAAACTGGCGATGGCAATCCGTGGCAGCAGTAACTATTACCAGATTTACAGAA
TATTAAGACGCCACTGGATCAAACATGGTGAGATGACTGGTCTTAGCAGGCAGCAGATCGAGATGATGATTGATGACATT
GTAACCGTGACGCCAGAGGTTATTGAACGCGTCTATGCACAACTTCCAGCTCACTTCCCACAAGAACTTGCTGAGAGTGT
TTTTGATGGAATGAGGCAGCAGTGCAGGCGTCTGAGCGAGAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10924.64 Da        Isoelectric Point: 10.4711

>AT94795 WP_103214936.1 NZ_CP026398:c223146-222850 [Klebsiella pneumoniae]
MKNVFPIKTLNQLRPLLLGFRKANGLTQKDVSERLGVTQQTYARLEANPASASIERLFKVFSVLGVEISLSSVKGSSEMM
LSGENESLESLPARREKW

Download         Length: 297 bp

>AT94795 NZ_CP026398:c223146-222850 [Klebsiella pneumoniae]
ATGAAAAATGTTTTTCCAATAAAAACACTCAACCAGTTGCGTCCATTGCTGCTTGGATTTCGCAAAGCGAATGGACTGAC
TCAAAAAGACGTTTCTGAGCGGTTAGGCGTAACCCAGCAGACTTACGCTCGCCTGGAGGCCAATCCAGCCAGTGCGAGTA
TTGAACGCCTGTTCAAAGTGTTTTCCGTGCTGGGAGTGGAAATCAGCCTTTCCTCGGTGAAAGGTTCATCAGAAATGATG
CTGTCGGGCGAAAATGAATCTTTGGAAAGTTTGCCCGCCAGACGAGAGAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References