Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3653201..3653976 Replicon chromosome
Accession NZ_CP026392
Organism Klebsiella pneumoniae strain KPNIH48

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1W1JAQ8
Locus tag C3F39_RS18715 Protein ID WP_009308645.1
Coordinates 3653491..3653976 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag C3F39_RS18710 Protein ID WP_004150912.1
Coordinates 3653201..3653494 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F39_RS18690 3648409..3649011 - 603 WP_032448122.1 short chain dehydrogenase -
C3F39_RS18695 3649109..3650020 + 912 WP_004181308.1 LysR family transcriptional regulator -
C3F39_RS18700 3650021..3651169 - 1149 WP_040236164.1 PLP-dependent aspartate aminotransferase family protein -
C3F39_RS18705 3651180..3652556 - 1377 WP_072269297.1 cystathionine beta-synthase -
C3F39_RS18710 3653201..3653494 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
C3F39_RS18715 3653491..3653976 + 486 WP_009308645.1 GNAT family N-acetyltransferase Toxin
C3F39_RS18720 3654327..3655307 + 981 WP_014386491.1 IS5-like element ISKpn26 family transposase -
C3F39_RS18730 3655880..3656473 + 594 WP_004188553.1 hypothetical protein -
C3F39_RS18735 3656570..3656786 + 217 Protein_3513 transposase -
C3F39_RS18745 3657393..3658265 + 873 WP_040236165.1 ParA family protein -
C3F39_RS18750 3658265..3658648 + 384 WP_040236166.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17595.60 Da        Isoelectric Point: 8.5144

>T94777 WP_009308645.1 NZ_CP026392:3653491-3653976 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T94777 NZ_CP026392:3653491-3653976 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT94777 WP_004150912.1 NZ_CP026392:3653201-3653494 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT94777 NZ_CP026392:3653201-3653494 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W1JAQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References