Detailed information of TA system TA094768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 5185775..5186409
• Replicon: chromosome
• Accession: NZ_CP026386
• Organism: Pseudomonas sp. PONIH3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2L0LXU2
• Locus tag: C3F42_RS24015
• Protein ID: WP_023630766.1
• Coordinates: 5185775..5185957 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C3F42_RS24020
• Protein ID: WP_104444997.1
• Coordinates: 5185978..5186409 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3F42_RS23990	5181759..5182853	+	1095	WP_023630763.1	iron-sulfur cluster carrier protein ApbC	-
C3F42_RS23995	5182976..5183185	-	210	WP_012273869.1	cold-shock protein	-
C3F42_RS24000	5183513..5184079	+	567	WP_023630764.1	dCTP deaminase	-
C3F42_RS24005	5184177..5184419	+	243	WP_046854466.1	hypothetical protein	-
C3F42_RS24010	5184426..5185541	-	1116	WP_104444996.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
C3F42_RS24015	5185775..5185957	+	183	WP_023630766.1	type II toxin-antitoxin system HicA family toxin	Toxin
C3F42_RS24020	5185978..5186409	+	432	WP_104444997.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C3F42_RS24025	5186473..5188908	-	2436	WP_104444998.1	penicillin acylase family protein	-
C3F42_RS24030	5189101..5189304	-	204	WP_023632501.1	SEC-C domain-containing protein	-
C3F42_RS24035	5189312..5189788	-	477	WP_023632502.1	LEA type 2 family protein	-
C3F42_RS24040	5189791..5190267	-	477	WP_038706657.1	YchJ family protein	-
C3F42_RS24045	5190272..5190766	-	495	WP_094012390.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	mucP / kdsA	4964397..5213395	248998

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-69)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6845.93 Da
• Isoelectric Point: 10.7459

>T94768 WP_023630766.1 NZ_CP026386:5185775-5185957 [Pseudomonas sp. PONIH3]
MKYSELRRWLRSQGATFVPAKGSHFKVYLGNRQTIFPDHGAKEIGEGLRKKILKDLGLSD

Nucleotide

• Length: 183 bp

>T94768 NZ_CP026386:5185775-5185957 [Pseudomonas sp. PONIH3]
ATGAAGTACAGCGAACTACGTCGATGGCTGCGTTCTCAGGGAGCCACCTTCGTTCCTGCCAAAGGCAGCCATTTCAAGGT
TTACCTGGGCAATCGACAAACCATCTTCCCCGACCACGGCGCCAAGGAAATAGGGGAGGGGCTGAGGAAGAAGATCCTCA
AGGATCTTGGACTGAGCGACTGA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15719.08 Da
• Isoelectric Point: 5.6004

>AT94768 WP_104444997.1 NZ_CP026386:5185978-5186409 [Pseudomonas sp. PONIH3]
MNFDYPVNVHRDTGSVWISCPDIPEMASAGDTLDEALFDAVDALESALSLYVERRAAIPLPTPVQSAEAIVRLPALTAAK
AALWNTMVSQNVTKTEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALHVLGQRIELAVVAALR

Nucleotide

• Length: 432 bp

>AT94768 NZ_CP026386:5185978-5186409 [Pseudomonas sp. PONIH3]
ATGAATTTCGACTATCCGGTAAACGTGCACCGTGATACAGGCAGTGTCTGGATCAGTTGTCCGGATATACCTGAGATGGC
CAGTGCGGGCGATACGCTCGATGAAGCATTGTTCGATGCAGTGGATGCCCTGGAGTCAGCGCTTTCCCTGTACGTGGAGC
GTCGGGCAGCCATTCCGTTGCCGACACCAGTGCAGTCAGCCGAGGCCATTGTCAGGTTGCCGGCGCTGACCGCGGCCAAG
GCGGCGCTGTGGAACACCATGGTCTCTCAGAACGTGACCAAGACCGAAATGGCCCGACGGCTTGGCGTTAATCGGCCGCA
GGTGGACCGGCTGGTTGATTTGCTGCATCGCTCCAAGATCGAGCAGGTCGAGCATGCCTTGCATGTATTGGGACAACGCA
TAGAACTCGCGGTGGTAGCTGCCTTAAGATGA

Structures

Toxin

• AlphaFold DB: A0A2L0LXU2