Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4776459..4776978 | Replicon | chromosome |
Accession | NZ_CP026386 | ||
Organism | Pseudomonas sp. PONIH3 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A1H9NMR5 |
Locus tag | C3F42_RS22205 | Protein ID | WP_023629498.1 |
Coordinates | 4776459..4776749 (-) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A2L0LWH9 |
Locus tag | C3F42_RS22210 | Protein ID | WP_023629499.1 |
Coordinates | 4776739..4776978 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C3F42_RS22175 | 4771815..4772882 | + | 1068 | WP_104444913.1 | XRE family transcriptional regulator | - |
C3F42_RS22180 | 4772863..4773348 | + | 486 | WP_104444914.1 | PIN domain-containing protein | - |
C3F42_RS22185 | 4773695..4774507 | + | 813 | WP_104444915.1 | alpha/beta hydrolase | - |
C3F42_RS22190 | 4774500..4775708 | + | 1209 | WP_177410841.1 | PAS domain-containing sensor histidine kinase | - |
C3F42_RS29465 | 4775763..4775915 | + | 153 | WP_158659585.1 | hypothetical protein | - |
C3F42_RS22200 | 4775942..4776175 | - | 234 | WP_031314705.1 | Phd-YefM | - |
C3F42_RS22205 | 4776459..4776749 | - | 291 | WP_023629498.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
C3F42_RS22210 | 4776739..4776978 | - | 240 | WP_023629499.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
C3F42_RS22215 | 4777070..4778557 | - | 1488 | WP_104444916.1 | methylenetetrahydrofolate reductase C-terminal domain-containing protein | - |
C3F42_RS22220 | 4778795..4781098 | + | 2304 | WP_104444917.1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase | - |
C3F42_RS22225 | 4781163..4781681 | + | 519 | WP_104444918.1 | histidine phosphatase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11378.22 Da Isoelectric Point: 10.2588
>T94767 WP_023629498.1 NZ_CP026386:c4776749-4776459 [Pseudomonas sp. PONIH3]
MTYNLDFDARALKEWQKLGDTIRQQLKKKLATVLLNPRVEANRLHGFPDCYKIKLRSSGYRLVYQVIDHQIVVFVVAVDK
RERDQVYRKAAERLTE
MTYNLDFDARALKEWQKLGDTIRQQLKKKLATVLLNPRVEANRLHGFPDCYKIKLRSSGYRLVYQVIDHQIVVFVVAVDK
RERDQVYRKAAERLTE
Download Length: 291 bp
>T94767 NZ_CP026386:c4776749-4776459 [Pseudomonas sp. PONIH3]
ATGACCTATAACCTCGATTTCGATGCGCGCGCACTCAAGGAATGGCAGAAGCTCGGCGACACCATTCGCCAACAGCTAAA
GAAGAAGCTGGCAACCGTGTTGCTCAACCCGAGGGTCGAAGCGAACCGTCTGCACGGTTTCCCGGACTGCTACAAGATCA
AGCTGCGCAGCAGCGGATATCGATTGGTCTATCAGGTCATCGATCATCAAATCGTGGTGTTTGTGGTCGCCGTGGATAAA
CGTGAGCGAGATCAGGTTTACCGCAAGGCGGCCGAACGATTGACCGAGTAA
ATGACCTATAACCTCGATTTCGATGCGCGCGCACTCAAGGAATGGCAGAAGCTCGGCGACACCATTCGCCAACAGCTAAA
GAAGAAGCTGGCAACCGTGTTGCTCAACCCGAGGGTCGAAGCGAACCGTCTGCACGGTTTCCCGGACTGCTACAAGATCA
AGCTGCGCAGCAGCGGATATCGATTGGTCTATCAGGTCATCGATCATCAAATCGTGGTGTTTGTGGTCGCCGTGGATAAA
CGTGAGCGAGATCAGGTTTACCGCAAGGCGGCCGAACGATTGACCGAGTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9050.45 Da Isoelectric Point: 4.8146
>AT94767 WP_023629499.1 NZ_CP026386:c4776978-4776739 [Pseudomonas sp. PONIH3]
MASINVRIDDDLKVRAYRELEKLGVTPSELMRQALQYVAERGQLPFKPVLLTEEDEALLATVRERLASPQRVRVTLDDL
MASINVRIDDDLKVRAYRELEKLGVTPSELMRQALQYVAERGQLPFKPVLLTEEDEALLATVRERLASPQRVRVTLDDL
Download Length: 240 bp
>AT94767 NZ_CP026386:c4776978-4776739 [Pseudomonas sp. PONIH3]
ATGGCGTCCATCAATGTACGTATCGACGACGACCTCAAGGTGCGCGCCTACCGTGAGCTGGAAAAGCTGGGTGTAACCCC
CTCCGAGCTGATGCGCCAAGCGCTGCAATATGTTGCTGAGCGCGGGCAACTGCCTTTTAAACCCGTGTTACTGACCGAAG
AGGACGAAGCACTGCTCGCCACGGTACGCGAACGCCTGGCCTCGCCGCAGAGGGTGAGGGTAACGCTGGATGACCTATAA
ATGGCGTCCATCAATGTACGTATCGACGACGACCTCAAGGTGCGCGCCTACCGTGAGCTGGAAAAGCTGGGTGTAACCCC
CTCCGAGCTGATGCGCCAAGCGCTGCAATATGTTGCTGAGCGCGGGCAACTGCCTTTTAAACCCGTGTTACTGACCGAAG
AGGACGAAGCACTGCTCGCCACGGTACGCGAACGCCTGGCCTCGCCGCAGAGGGTGAGGGTAACGCTGGATGACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1H9NMR5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2L0LWH9 |