Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4776459..4776978 Replicon chromosome
Accession NZ_CP026386
Organism Pseudomonas sp. PONIH3

Toxin (Protein)


Gene name relE Uniprot ID A0A1H9NMR5
Locus tag C3F42_RS22205 Protein ID WP_023629498.1
Coordinates 4776459..4776749 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2L0LWH9
Locus tag C3F42_RS22210 Protein ID WP_023629499.1
Coordinates 4776739..4776978 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F42_RS22175 4771815..4772882 + 1068 WP_104444913.1 XRE family transcriptional regulator -
C3F42_RS22180 4772863..4773348 + 486 WP_104444914.1 PIN domain-containing protein -
C3F42_RS22185 4773695..4774507 + 813 WP_104444915.1 alpha/beta hydrolase -
C3F42_RS22190 4774500..4775708 + 1209 WP_177410841.1 PAS domain-containing sensor histidine kinase -
C3F42_RS29465 4775763..4775915 + 153 WP_158659585.1 hypothetical protein -
C3F42_RS22200 4775942..4776175 - 234 WP_031314705.1 Phd-YefM -
C3F42_RS22205 4776459..4776749 - 291 WP_023629498.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C3F42_RS22210 4776739..4776978 - 240 WP_023629499.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C3F42_RS22215 4777070..4778557 - 1488 WP_104444916.1 methylenetetrahydrofolate reductase C-terminal domain-containing protein -
C3F42_RS22220 4778795..4781098 + 2304 WP_104444917.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
C3F42_RS22225 4781163..4781681 + 519 WP_104444918.1 histidine phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11378.22 Da        Isoelectric Point: 10.2588

>T94767 WP_023629498.1 NZ_CP026386:c4776749-4776459 [Pseudomonas sp. PONIH3]
MTYNLDFDARALKEWQKLGDTIRQQLKKKLATVLLNPRVEANRLHGFPDCYKIKLRSSGYRLVYQVIDHQIVVFVVAVDK
RERDQVYRKAAERLTE

Download         Length: 291 bp

>T94767 NZ_CP026386:c4776749-4776459 [Pseudomonas sp. PONIH3]
ATGACCTATAACCTCGATTTCGATGCGCGCGCACTCAAGGAATGGCAGAAGCTCGGCGACACCATTCGCCAACAGCTAAA
GAAGAAGCTGGCAACCGTGTTGCTCAACCCGAGGGTCGAAGCGAACCGTCTGCACGGTTTCCCGGACTGCTACAAGATCA
AGCTGCGCAGCAGCGGATATCGATTGGTCTATCAGGTCATCGATCATCAAATCGTGGTGTTTGTGGTCGCCGTGGATAAA
CGTGAGCGAGATCAGGTTTACCGCAAGGCGGCCGAACGATTGACCGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9050.45 Da        Isoelectric Point: 4.8146

>AT94767 WP_023629499.1 NZ_CP026386:c4776978-4776739 [Pseudomonas sp. PONIH3]
MASINVRIDDDLKVRAYRELEKLGVTPSELMRQALQYVAERGQLPFKPVLLTEEDEALLATVRERLASPQRVRVTLDDL

Download         Length: 240 bp

>AT94767 NZ_CP026386:c4776978-4776739 [Pseudomonas sp. PONIH3]
ATGGCGTCCATCAATGTACGTATCGACGACGACCTCAAGGTGCGCGCCTACCGTGAGCTGGAAAAGCTGGGTGTAACCCC
CTCCGAGCTGATGCGCCAAGCGCTGCAATATGTTGCTGAGCGCGGGCAACTGCCTTTTAAACCCGTGTTACTGACCGAAG
AGGACGAAGCACTGCTCGCCACGGTACGCGAACGCCTGGCCTCGCCGCAGAGGGTGAGGGTAACGCTGGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H9NMR5

Antitoxin

Source ID Structure
AlphaFold DB A0A2L0LWH9

References