Detailed information of TA system TA094766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4511206..4511846
• Replicon: chromosome
• Accession: NZ_CP026386
• Organism: Pseudomonas sp. PONIH3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1H9S264
• Locus tag: C3F42_RS20925
• Protein ID: WP_028691288.1
• Coordinates: 4511206..4511616 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: C3F42_RS20930
• Protein ID: WP_094012238.1
• Coordinates: 4511616..4511846 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3F42_RS20900	4508335..4508760	-	426	WP_023631117.1	DUF2946 domain-containing protein	-
C3F42_RS20905	4508781..4509266	-	486	WP_023631116.1	copper chaperone PCu(A)C	-
C3F42_RS20910	4509314..4509703	-	390	WP_094012237.1	DUF2946 domain-containing protein	-
C3F42_RS20915	4509815..4510669	-	855	WP_023631114.1	SPFH/Band 7/PHB domain protein	-
C3F42_RS20920	4510696..4511133	-	438	WP_088852331.1	NfeD family protein	-
C3F42_RS20925	4511206..4511616	-	411	WP_028691288.1	tRNA(fMet)-specific endonuclease VapC	Toxin
C3F42_RS20930	4511616..4511846	-	231	WP_094012238.1	antitoxin	Antitoxin
C3F42_RS20935	4511929..4512657	-	729	WP_028691287.1	cobalt-precorrin-6A reductase	-
C3F42_RS20940	4512654..4513748	-	1095	WP_094012239.1	cobalt-precorrin-5B (C(1))-methyltransferase	-
C3F42_RS20945	4513741..4514952	-	1212	WP_104445328.1	precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE	-
C3F42_RS20950	4515064..4516389	+	1326	WP_038706878.1	precorrin-3B synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15234.59 Da
• Isoelectric Point: 9.5447

>T94766 WP_028691288.1 NZ_CP026386:c4511616-4511206 [Pseudomonas sp. PONIH3]
MLRYMLDTNICIFTIKNKPQVVREAFNRHHGQLAISTVTLMELIYGAEKSAAPERNLAIVEGFAARLDVLDYDIQGAAHT
AQLRAELAKAGTPIGPYDRMIAGHARARGLTLVTNNLREFQRVPGLRVEDWVTHPR

Nucleotide

• Length: 411 bp

>T94766 NZ_CP026386:c4511616-4511206 [Pseudomonas sp. PONIH3]
ATGCTCAGGTACATGCTCGATACCAACATCTGCATTTTCACCATCAAGAACAAGCCACAAGTGGTGCGCGAGGCATTCAA
TCGGCACCACGGCCAGTTGGCCATCAGCACGGTAACCCTGATGGAGTTGATCTACGGTGCGGAAAAGTCCGCCGCGCCGG
AGCGTAATCTGGCCATTGTCGAGGGGTTCGCCGCACGGCTCGATGTGCTTGACTACGACATTCAGGGCGCAGCTCACACC
GCGCAGCTACGTGCGGAACTGGCCAAGGCCGGCACGCCCATCGGCCCCTACGACAGAATGATTGCCGGCCACGCCCGCGC
GCGCGGCCTCACGCTGGTGACCAACAACCTGCGCGAGTTCCAGCGTGTTCCGGGGCTGCGTGTGGAAGATTGGGTGACAC
ATCCACGCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8445.33 Da
• Isoelectric Point: 4.2683

>AT94766 WP_094012238.1 NZ_CP026386:c4511846-4511616 [Pseudomonas sp. PONIH3]
MEQGAVFKSNRSQAIRMPKALALPDDVTRVDIVAVGRSRIISPAGESWDSWFEGDDVSSDFMASREQPADQEREGF

Nucleotide

• Length: 231 bp

>AT94766 NZ_CP026386:c4511846-4511616 [Pseudomonas sp. PONIH3]
ATGGAGCAAGGTGCAGTCTTCAAAAGCAACCGCAGCCAGGCTATCCGCATGCCAAAAGCCCTCGCCCTTCCAGACGACGT
CACCCGAGTGGACATCGTCGCGGTGGGCCGTTCCCGTATCATCTCGCCTGCCGGCGAAAGCTGGGACAGCTGGTTCGAGG
GTGACGATGTGAGTTCGGACTTCATGGCGAGCAGGGAACAGCCAGCCGACCAGGAGCGCGAAGGATTCTGA

Structures

Toxin

• AlphaFold DB: A0A1H9S264