Detailed information of TA system TA094765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4133402..4134024
• Replicon: chromosome
• Accession: NZ_CP026386
• Organism: Pseudomonas sp. PONIH3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1H9I4P8
• Locus tag: C3F42_RS19185
• Protein ID: WP_023630583.1
• Coordinates: 4133402..4133593 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C3F42_RS19190
• Protein ID: WP_094010983.1
• Coordinates: 4133611..4134024 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3F42_RS19165	4128757..4129815	+	1059	WP_094010979.1	putative 2-aminoethylphosphonate ABC transporter ATP-binding protein	-
C3F42_RS19170	4129817..4131541	+	1725	WP_104444761.1	putative 2-aminoethylphosphonate ABC transporter permease subunit	-
C3F42_RS19175	4131572..4132594	+	1023	WP_094010981.1	putative 2-aminoethylphosphonate ABC transporter substrate-binding protein	-
C3F42_RS19180	4132678..4133223	+	546	WP_094010982.1	HDIG domain-containing protein	-
C3F42_RS19185	4133402..4133593	+	192	WP_023630583.1	type II toxin-antitoxin system HicA family toxin	Toxin
C3F42_RS19190	4133611..4134024	+	414	WP_094010983.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C3F42_RS19195	4134025..4135404	-	1380	WP_104444762.1	HAMP domain-containing protein	-
C3F42_RS19200	4135406..4136125	-	720	WP_023629985.1	response regulator	-
C3F42_RS19205	4136266..4138560	+	2295	WP_094010984.1	TonB-dependent siderophore receptor	-
C3F42_RS19210	4138649..4138900	+	252	WP_094010985.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7077.22 Da
• Isoelectric Point: 10.2291

>T94765 WP_023630583.1 NZ_CP026386:4133402-4133593 [Pseudomonas sp. PONIH3]
MNSREMIAVIEADGWYLVRSKGSHHHFKHPEKAGLVTIPHPRKDLLPATAASILRQARICYAS

Nucleotide

• Length: 192 bp

>T94765 NZ_CP026386:4133402-4133593 [Pseudomonas sp. PONIH3]
ATGAACAGCCGTGAAATGATTGCTGTGATCGAGGCGGATGGCTGGTATCTGGTGCGCTCCAAAGGCAGCCACCATCATTT
CAAGCATCCTGAAAAAGCCGGGCTGGTCACCATCCCGCATCCCAGGAAAGACCTGCTGCCCGCGACTGCGGCCAGCATCC
TGCGCCAGGCACGCATCTGCTACGCCAGCTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 14900.94 Da
• Isoelectric Point: 4.7269

>AT94765 WP_094010983.1 NZ_CP026386:4133611-4134024 [Pseudomonas sp. PONIH3]
MLFPIAILPGDDQHAWGVEVPDIPGCFSAGEDLDNAIAMAREAIEGHLELLAQDQQEIPRASKVGVHAANPAYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALRILQGDGK

Nucleotide

• Length: 414 bp

>AT94765 NZ_CP026386:4133611-4134024 [Pseudomonas sp. PONIH3]
ATGTTGTTCCCTATCGCGATCCTCCCCGGTGACGACCAGCACGCCTGGGGCGTGGAAGTCCCGGATATCCCTGGCTGCTT
TTCGGCGGGCGAAGACCTCGACAACGCCATCGCCATGGCGCGTGAAGCGATCGAAGGCCACCTCGAACTCCTGGCCCAGG
ACCAGCAGGAAATCCCCAGGGCCAGCAAGGTCGGCGTGCATGCGGCCAACCCCGCCTATGCCGGCTGCACCTGGGCACTG
ATCGATATCGACATCACCCGCTACCTGGGCAAGGCCGAGAAGCTCAACATCACCTTGCCGGCGTACCTGCTCACCCGCAT
CGACAGCTACGTACAGAACCACCCGGAGCACAAGAGCCGTTCGGGCTTCCTGGCCGAGGCGGCGCTGAGGATCCTGCAGG
GTGATGGCAAATGA

Structures

Toxin

• AlphaFold DB: A0A1H9I4P8