Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4759639..4760308 Replicon chromosome
Accession NZ_CP026383
Organism Serratia sp. SSNIH1

Toxin (Protein)


Gene name cptA Uniprot ID A0A5P6GZ53
Locus tag C3F38_RS22925 Protein ID WP_047729923.1
Coordinates 4759639..4760061 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8B4GS04
Locus tag C3F38_RS22930 Protein ID WP_019455657.1
Coordinates 4760042..4760308 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F38_RS22905 4755529..4756047 + 519 WP_038871234.1 flavodoxin FldB -
C3F38_RS22910 4756084..4757448 - 1365 WP_047729926.1 cell envelope integrity protein CreD -
C3F38_RS22915 4757529..4758947 - 1419 WP_055316662.1 two-component system sensor histidine kinase CreC -
C3F38_RS22920 4758944..4759639 - 696 WP_055316660.1 two-component system response regulator CreB -
C3F38_RS22925 4759639..4760061 - 423 WP_047729923.1 protein YgfX Toxin
C3F38_RS22930 4760042..4760308 - 267 WP_019455657.1 FAD assembly factor SdhE Antitoxin
C3F38_RS22935 4760629..4761621 + 993 WP_047729922.1 tRNA-modifying protein YgfZ -
C3F38_RS22940 4761660..4762157 - 498 WP_038871226.1 DUF2165 domain-containing protein -
C3F38_RS22945 4762308..4762982 - 675 WP_038871224.1 hemolysin III family protein -
C3F38_RS22950 4763166..4763774 + 609 WP_025304127.1 HD domain-containing protein -
C3F38_RS22955 4763807..4764733 - 927 WP_047729921.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16500.57 Da        Isoelectric Point: 10.8114

>T94761 WP_047729923.1 NZ_CP026383:c4760061-4759639 [Serratia sp. SSNIH1]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPVGDGEEA

Download         Length: 423 bp

>T94761 NZ_CP026383:c4760061-4759639 [Serratia sp. SSNIH1]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACTCAGCTGTTTTCCCTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGTCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGTTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
TGGGTGACGGCGAGGAGGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10417.91 Da        Isoelectric Point: 4.7921

>AT94761 WP_019455657.1 NZ_CP026383:c4760308-4760042 [Serratia sp. SSNIH1]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT94761 NZ_CP026383:c4760308-4760042 [Serratia sp. SSNIH1]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P6GZ53

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GS04

References