Detailed information of TA system TA094760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4400963..4401619
• Replicon: chromosome
• Accession: NZ_CP026383
• Organism: Serratia sp. SSNIH1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5C7DE55
• Locus tag: C3F38_RS21230
• Protein ID: WP_047730091.1
• Coordinates: 4400963..4401352 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: C3F38_RS21235
• Protein ID: WP_004941563.1
• Coordinates: 4401356..4401619 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3F38_RS21215	4397432..4398862	+	1431	WP_060434507.1	MFS transporter	-
C3F38_RS21220	4398859..4400232	+	1374	WP_060434510.1	two-component system sensor histidine kinase BaeS	-
C3F38_RS21225	4400242..4400958	+	717	WP_047730092.1	two-component system response regulator BaeR	-
C3F38_RS21230	4400963..4401352	-	390	WP_047730091.1	type II toxin-antitoxin system VapC family toxin	Toxin
C3F38_RS21235	4401356..4401619	-	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
C3F38_RS21240	4401958..4402296	+	339	WP_038873760.1	YegP family protein	-
C3F38_RS21245	4402598..4403950	+	1353	WP_038873761.1	tRNA 5-hydroxyuridine modification protein YegQ	-
C3F38_RS21250	4404418..4405323	+	906	WP_038873764.1	lipid kinase YegS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14337.57 Da
• Isoelectric Point: 7.8794

>T94760 WP_047730091.1 NZ_CP026383:c4401352-4400963 [Serratia sp. SSNIH1]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T94760 NZ_CP026383:c4401352-4400963 [Serratia sp. SSNIH1]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAAGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAGAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT94760 WP_004941563.1 NZ_CP026383:c4401619-4401356 [Serratia sp. SSNIH1]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT94760 NZ_CP026383:c4401619-4401356 [Serratia sp. SSNIH1]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Structures

Toxin

• AlphaFold DB: A0A5C7DE55