Detailed information of TA system TA094759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4320334..4320896
• Replicon: chromosome
• Accession: NZ_CP026383
• Organism: Serratia sp. SSNIH1

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A2F0Q0H7
• Locus tag: C3F38_RS20855
• Protein ID: WP_033635474.1
• Coordinates: 4320334..4320690 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A8G2G5I1
• Locus tag: C3F38_RS20860
• Protein ID: WP_004936539.1
• Coordinates: 4320687..4320896 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3F38_RS20835	4316069..4316866	-	798	WP_055317351.1	energy transducer TonB	-
C3F38_RS20840	4316969..4317808	-	840	WP_057523627.1	ChaN family lipoprotein	-
C3F38_RS20845	4317986..4319395	+	1410	WP_104456925.1	S-methylmethionine permease	-
C3F38_RS20850	4319385..4320323	+	939	WP_055317650.1	homocysteine S-methyltransferase	-
C3F38_RS20855	4320334..4320690	-	357	WP_033635474.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
C3F38_RS20860	4320687..4320896	-	210	WP_004936539.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
C3F38_RS20865	4321006..4323285	-	2280	WP_038881248.1	NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase	-
C3F38_RS26445	4323501..4323674	-	174	WP_038881246.1	hypothetical protein	-
C3F38_RS20870	4323655..4324035	-	381	WP_055317467.1	DUF2570 family protein	-
C3F38_RS20875	4324032..4324433	-	402	WP_038881240.1	M15 family metallopeptidase	-
C3F38_RS20880	4324423..4324749	-	327	WP_004936551.1	phage holin, lambda family	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (20-114)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13120.90 Da
• Isoelectric Point: 4.7246

>T94759 WP_033635474.1 NZ_CP026383:c4320690-4320334 [Serratia sp. SSNIH1]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRLLTE

Nucleotide

• Length: 357 bp

>T94759 NZ_CP026383:c4320690-4320334 [Serratia sp. SSNIH1]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAATGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAGCAAAGT
TGAGGCTGTAGCCAACCGCGTGCTCAATGCTTACCACTACGAAAACGTCACCGACGTTTATCGTTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGATGCAGAATTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCTGCTAACCGAATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7749.96 Da
• Isoelectric Point: 10.1768

>AT94759 WP_004936539.1 NZ_CP026383:c4320896-4320687 [Serratia sp. SSNIH1]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Nucleotide

• Length: 210 bp

>AT94759 NZ_CP026383:c4320896-4320687 [Serratia sp. SSNIH1]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTTTTGGTCAAAGCCAAGGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Structures

Toxin

• AlphaFold DB: A0A2F0Q0H7