Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1587241..1587863 Replicon chromosome
Accession NZ_CP026383
Organism Serratia sp. SSNIH1

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag C3F38_RS07605 Protein ID WP_004940313.1
Coordinates 1587241..1587444 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag C3F38_RS07610 Protein ID WP_004940312.1
Coordinates 1587495..1587863 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F38_RS07580 1583049..1583495 + 447 WP_055316525.1 type II secretion system protein M -
C3F38_RS07585 1583532..1584347 + 816 WP_055316523.1 A24 family peptidase -
C3F38_RS07590 1584344..1584706 - 363 WP_055316521.1 type II secretion system pilot lipoprotein GspS -
C3F38_RS07595 1584959..1586386 + 1428 WP_055313421.1 N-acetylglucosamine-binding protein GbpA -
C3F38_RS07600 1586439..1586957 + 519 WP_047728667.1 cytochrome b/b6 domain-containing protein -
C3F38_RS07605 1587241..1587444 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
C3F38_RS07610 1587495..1587863 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
C3F38_RS07615 1588022..1588375 - 354 WP_055316517.1 hypothetical protein -
C3F38_RS07620 1588785..1589498 + 714 WP_055316516.1 ABC transporter ATP-binding protein -
C3F38_RS07625 1589495..1590352 + 858 WP_038874980.1 metal ABC transporter permease -
C3F38_RS07630 1590378..1591256 + 879 WP_038874983.1 zinc ABC transporter substrate-binding protein -
C3F38_RS07635 1591363..1591503 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
C3F38_RS07640 1591516..1591770 - 255 WP_038874985.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T94749 WP_004940313.1 NZ_CP026383:c1587444-1587241 [Serratia sp. SSNIH1]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T94749 NZ_CP026383:c1587444-1587241 [Serratia sp. SSNIH1]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT94749 WP_004940312.1 NZ_CP026383:c1587863-1587495 [Serratia sp. SSNIH1]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT94749 NZ_CP026383:c1587863-1587495 [Serratia sp. SSNIH1]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
GACCTTGGGAGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACTTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAGACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References