Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1001593..1003213 Replicon chromosome
Accession NZ_CP026383
Organism Serratia sp. SSNIH1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C3F38_RS04760 Protein ID WP_055317393.1
Coordinates 1001894..1003213 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C3F38_RS04755 Protein ID WP_071934088.1
Coordinates 1001593..1001889 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F38_RS04730 997894..998859 - 966 WP_055317390.1 SDR family oxidoreductase -
C3F38_RS04735 998890..999657 - 768 WP_033636886.1 DeoR/GlpR family DNA-binding transcription regulator -
C3F38_RS26105 999713..999967 - 255 WP_139108047.1 hypothetical protein -
C3F38_RS04745 1000348..1000872 + 525 WP_055317391.1 hypothetical protein -
C3F38_RS04750 1000869..1001249 + 381 WP_055317392.1 hypothetical protein -
C3F38_RS26110 1001271..1001516 - 246 WP_139108046.1 hypothetical protein -
C3F38_RS04755 1001593..1001889 + 297 WP_071934088.1 helix-turn-helix transcriptional regulator Antitoxin
C3F38_RS04760 1001894..1003213 + 1320 WP_055317393.1 type II toxin-antitoxin system HipA family toxin Toxin
C3F38_RS04765 1003431..1007033 - 3603 WP_100247382.1 hypothetical protein -
C3F38_RS04770 1007089..1007511 + 423 WP_080479040.1 DNA mismatch endonuclease Vsr -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 998890..1011143 12253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-71)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49768.75 Da        Isoelectric Point: 6.1390

>T94748 WP_055317393.1 NZ_CP026383:1001894-1003213 [Serratia sp. SSNIH1]
MRRSQQRLAIWMNGIPVGYWEKRRGEDRLEYLPEWIADSQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSEGIRRRL
AMRYHADSLDPFDLLAELGRDCVGAIQLLDIGEQPADIFSIRQRPLAEAQIAEMLRNTTTTLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGLVGNMRADMSTSIENEWLCSLIVENYGVPVASTHIAQFEDQKALIVERFD
RKLSSDKQWWIRLPQEDMCQALGVSPLRKYQSDGGPGITDIMEILSRSEQAETDRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNNQIAWQKCKLAMAVRGSSNHYLLSQIRRRHWIKHGEITGLGQQEVESIIEELL
AATPGVIDRVIGLLPDSFPAELAECIFEGIRQQCARLVG

Download         Length: 1320 bp

>T94748 NZ_CP026383:1001894-1003213 [Serratia sp. SSNIH1]
ATGCGTCGTTCGCAACAACGGTTAGCTATCTGGATGAACGGTATTCCGGTGGGATATTGGGAAAAGCGTAGAGGTGAGGA
TCGGCTTGAGTATCTGCCAGAGTGGATTGCAGATAGTCAGGGGAGGCCTTTGTCGCTTTCTTTGCCTTTCACGCCGGGGA
ATCAGCCTTATCGCGGTAGCGTGGTGCGCGATTATTTCGATAACCTGCTGCCAGATAGCGAGGGGATCCGCCGACGTTTG
GCTATGCGCTATCATGCCGACAGTCTGGACCCTTTCGACTTATTGGCCGAACTGGGCCGCGACTGTGTTGGTGCCATACA
GCTTCTCGATATCGGTGAGCAACCTGCGGATATATTTTCCATCAGGCAACGCCCGCTGGCAGAGGCGCAAATCGCCGAAA
TGCTCCGCAATACCACCACGACGTTACCGGGGCGACAGGGGCAGGATGACGATCTGCGTTTATCCATCGCCGGCGCCCAG
GAAAAAACGGCGCTGCTGTGGCATGACAACCAGTGGTGTTTACCTGAGGGAAATACGCCGACCACGCATATTTTCAAATT
AGCGCTAGGTCTGGTCGGAAACATGCGGGCCGATATGAGCACGTCCATCGAGAATGAATGGCTCTGCTCCCTGATTGTTG
AAAACTATGGTGTGCCAGTAGCAAGTACCCATATTGCGCAGTTTGAAGATCAAAAGGCACTGATCGTTGAGCGTTTTGAC
AGGAAACTATCAAGCGATAAACAGTGGTGGATCCGCCTGCCGCAAGAGGATATGTGCCAGGCTCTGGGCGTTTCGCCGCT
GAGGAAGTATCAATCAGACGGTGGCCCCGGCATTACCGATATTATGGAAATTCTGAGTCGCTCGGAACAGGCTGAAACAG
ATCGCAGGCACTTCTTTAAAGCGCAGATTATTTTTTGGCTGCTGGCCGCGACAGATGGCCACGCAAAGAATTTCAGTCTT
GCGCATTTACCCCAAAATCGTTACCACCTGACGCCACTGTACGATGTGCTATCGGCCTGGCCGCTGATTGGCCCGGGCAA
TAACCAGATAGCCTGGCAGAAGTGCAAACTGGCGATGGCCGTTCGAGGGAGCAGTAACCATTACCTGCTTAGCCAGATCC
GACGCCGCCACTGGATAAAACACGGTGAAATAACCGGGTTAGGCCAACAGGAGGTTGAATCCATTATTGAAGAGCTGCTG
GCAGCAACCCCGGGAGTGATTGATCGTGTCATTGGACTGCTACCTGATTCGTTCCCAGCCGAATTAGCGGAATGCATTTT
TGAGGGTATCAGGCAGCAGTGCGCGCGGTTGGTAGGGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10983.58 Da        Isoelectric Point: 9.0641

>AT94748 WP_071934088.1 NZ_CP026383:1001593-1001889 [Serratia sp. SSNIH1]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEMVLFSALASPGCE
TEETSTTHIDSPARREQW

Download         Length: 297 bp

>AT94748 NZ_CP026383:1001593-1001889 [Serratia sp. SSNIH1]
ATGAATACCGTCTATCCGTTAAAAACACTGAGCCAGCTACGCCCTTTGCTGGTGGGGTTTCGTAAAGCAAAAGGCCTGAC
GCAAAAAGACGTTTCGGAGAGGCTGGGCGTTACTCAACAGACCTATGCGCGCCTGGAGTCAAACCCTGCTTCAGCCAGTC
TGGAGCGCCTTTTTAGGGTGTTTAATGTGCTGGGGATTGAAATGGTGCTTTTCTCAGCGCTTGCCTCCCCGGGATGTGAA
ACGGAAGAAACCTCTACAACTCATATAGACTCGCCTGCAAGACGGGAACAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References