Detailed information of TA system TA094746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 680354..680826
• Replicon: chromosome
• Accession: NZ_CP026383
• Organism: Serratia sp. SSNIH1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5P6GNV0
• Locus tag: C3F38_RS03260
• Protein ID: WP_048232401.1
• Coordinates: 680551..680826 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C3F38_RS03255
• Protein ID: WP_033649649.1
• Coordinates: 680354..680551 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3F38_RS03225	675542..676810	+	1269	WP_055313077.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-
C3F38_RS03230	676807..678006	+	1200	WP_055317090.1	anaerobic glycerol-3-phosphate dehydrogenase subunit C	-
C3F38_RS03235	678042..678605	-	564	WP_047729417.1	DcrB family lipoprotein	-
C3F38_RS03240	678686..679120	-	435	WP_103767498.1	GNAT family N-acetyltransferase	-
C3F38_RS03245	679167..679826	-	660	WP_047729415.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
C3F38_RS03250	680047..680292	+	246	WP_025304890.1	sulfurtransferase TusA	-
C3F38_RS03255	680354..680551	+	198	WP_033649649.1	hypothetical protein	Antitoxin
C3F38_RS03260	680551..680826	+	276	WP_048232401.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
C3F38_RS03265	680886..683198	-	2313	WP_055317089.1	zinc/cadmium/mercury/lead-transporting ATPase	-
C3F38_RS03270	683881..685344	+	1464	WP_038874135.1	serralysin family metalloprotease	-
C3F38_RS03275	685400..685777	+	378	WP_038874139.1	AprI/Inh family metalloprotease inhibitor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10666.57 Da
• Isoelectric Point: 11.2806

>T94746 WP_048232401.1 NZ_CP026383:680551-680826 [Serratia sp. SSNIH1]
MLNIEWTRVARQDLGEIVGFIANDNPLAARKMKALIMEAVIPAARHPRIFRRGRVDGTHEIPLHPHYLLVYQVLETHIRV
LRVLHTRRQYP

Nucleotide

• Length: 276 bp

>T94746 NZ_CP026383:680551-680826 [Serratia sp. SSNIH1]
ATGCTCAACATCGAATGGACTCGAGTCGCACGTCAGGATCTGGGGGAGATTGTGGGATTTATCGCCAATGATAACCCTCT
GGCGGCCAGAAAAATGAAGGCTCTCATCATGGAGGCCGTCATTCCCGCCGCCAGACATCCTCGAATTTTCCGGCGCGGCA
GAGTGGACGGCACGCATGAAATCCCCCTGCATCCCCATTATCTCCTGGTTTACCAGGTGCTGGAAACTCACATCCGGGTG
TTGCGGGTTTTACATACGCGCCGACAATATCCTTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7398.49 Da
• Isoelectric Point: 4.4143

>AT94746 WP_033649649.1 NZ_CP026383:680354-680551 [Serratia sp. SSNIH1]
MSILLLPTVAKMENEERTQGYERWFLERVQEAMDEPRPGIPHDDVMAEMDAVIAAAEARIKAKQA

Nucleotide

• Length: 198 bp

>AT94746 NZ_CP026383:680354-680551 [Serratia sp. SSNIH1]
ATGAGTATTTTACTGCTGCCTACGGTTGCCAAGATGGAAAATGAGGAGCGTACACAGGGCTATGAGCGCTGGTTTCTTGA
AAGAGTTCAGGAAGCCATGGATGAGCCACGGCCCGGTATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTATCG
CTGCTGCAGAAGCCAGGATCAAAGCGAAGCAGGCATAA

Structures

Toxin

• AlphaFold DB: A0A5P6GNV0