Detailed information of TA system TA094743

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 495951..496552
• Replicon: chromosome
• Accession: NZ_CP026383
• Organism: Serratia sp. SSNIH1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C3F38_RS02370
• Protein ID: WP_055317375.1
• Coordinates: 495951..496331 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0G3SPC0
• Locus tag: C3F38_RS02375
• Protein ID: WP_038875999.1
• Coordinates: 496331..496552 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3F38_RS02345	491204..492484	+	1281	WP_104456907.1	DUF3748 domain-containing protein	-
C3F38_RS02350	492515..492862	-	348	WP_016929593.1	YceK/YidQ family lipoprotein	-
C3F38_RS02355	493172..493585	+	414	WP_004933919.1	heat shock chaperone IbpA	-
C3F38_RS02360	493686..494114	+	429	WP_004933922.1	heat shock chaperone IbpB	-
C3F38_RS02365	494282..495940	+	1659	WP_047729572.1	putative transporter	-
C3F38_RS02370	495951..496331	-	381	WP_055317375.1	type II toxin-antitoxin system VapC family toxin	Toxin
C3F38_RS02375	496331..496552	-	222	WP_038875999.1	ribbon-helix-helix domain-containing protein	Antitoxin
C3F38_RS02380	496627..497877	-	1251	WP_038875998.1	valine--pyruvate transaminase	-
C3F38_RS02385	498013..500076	-	2064	WP_055317376.1	alpha-amylase	-
C3F38_RS26340	500272..500424	+	153	WP_164491939.1	hypothetical protein	-
C3F38_RS02390	500426..501403	-	978	WP_055317377.1	glyoxylate/hydroxypyruvate reductase GhrB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-102)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 14215.56 Da
• Isoelectric Point: 7.3170

>T94743 WP_055317375.1 NZ_CP026383:c496331-495951 [Serratia sp. SSNIH1]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPTLELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Nucleotide

• Length: 381 bp

>T94743 NZ_CP026383:c496331-495951 [Serratia sp. SSNIH1]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGA
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8563.50 Da
• Isoelectric Point: 4.4791

>AT94743 WP_038875999.1 NZ_CP026383:c496552-496331 [Serratia sp. SSNIH1]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLAENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Nucleotide

• Length: 222 bp

>AT94743 NZ_CP026383:c496552-496331 [Serratia sp. SSNIH1]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGGCGGAGAACCACGTTGAAGATCCCAGCAATGCCTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0G3SPC0