Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3644455..3645109 Replicon chromosome
Accession NZ_CP026381
Organism Sphingopyxis sp. MG

Toxin (Protein)


Gene name vapC Uniprot ID A0A2L0VTQ5
Locus tag C3E99_RS16675 Protein ID WP_067112639.1
Coordinates 3644455..3644856 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2L0VTM1
Locus tag C3E99_RS16680 Protein ID WP_067112637.1
Coordinates 3644861..3645109 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3E99_RS16660 3641011..3641877 - 867 WP_067186469.1 3-hydroxybutyryl-CoA dehydrogenase -
C3E99_RS16665 3642013..3642999 - 987 WP_067112645.1 L-histidine N(alpha)-methyltransferase -
C3E99_RS16670 3643001..3644308 - 1308 WP_067186470.1 ergothioneine biosynthesis protein EgtB -
C3E99_RS16675 3644455..3644856 - 402 WP_067112639.1 type II toxin-antitoxin system VapC family toxin Toxin
C3E99_RS16680 3644861..3645109 - 249 WP_067112637.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C3E99_RS16685 3645339..3645920 - 582 WP_067186472.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
C3E99_RS16690 3646040..3646264 - 225 WP_067113372.1 HIG1 domain-containing protein -
C3E99_RS16695 3646274..3647125 - 852 WP_067186474.1 tRNA glutamyl-Q(34) synthetase GluQRS -
C3E99_RS16700 3647294..3647860 + 567 WP_067113387.1 HNH endonuclease -
C3E99_RS16705 3647942..3648364 + 423 WP_199775028.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14549.46 Da        Isoelectric Point: 4.9473

>T94742 WP_067112639.1 NZ_CP026381:c3644856-3644455 [Sphingopyxis sp. MG]
VIIDTSALVAILYHEPEGPSFVRLIHDAESCRISVANHVELSMVVESQLGPQGMRQAENFFRRAGIAIEPVTVEQGELAR
QAFLDYGKGRHKAGLNFGDCFAYALAKAAGEPLLFKGDDFARTDIEAAWSGER

Download         Length: 402 bp

>T94742 NZ_CP026381:c3644856-3644455 [Sphingopyxis sp. MG]
GTGATAATCGACACTTCTGCTCTGGTCGCGATCCTTTATCACGAACCCGAAGGTCCGTCCTTCGTCCGGCTGATCCATGA
TGCCGAAAGCTGTCGCATCAGCGTCGCCAATCATGTCGAATTATCGATGGTCGTCGAAAGCCAGCTCGGACCCCAAGGGA
TGCGTCAGGCGGAAAACTTCTTTCGGCGCGCAGGCATCGCGATCGAACCCGTGACGGTCGAACAGGGCGAGCTGGCCCGA
CAGGCCTTTCTCGACTACGGCAAGGGACGCCACAAGGCCGGGCTGAACTTCGGCGACTGCTTCGCCTATGCCCTGGCGAA
GGCGGCGGGCGAGCCGCTGCTGTTCAAAGGCGATGATTTCGCACGGACCGATATCGAGGCGGCCTGGAGCGGCGAGCGGT
AG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9012.28 Da        Isoelectric Point: 10.2944

>AT94742 WP_067112637.1 NZ_CP026381:c3645109-3644861 [Sphingopyxis sp. MG]
VSLNVKDPEAHRLAQAIARATGQSMTRVVTDALRDRLAAIQRRKARASVEELLAIADRAAAHVKRPYADHAELLYDDAGL
PR

Download         Length: 249 bp

>AT94742 NZ_CP026381:c3645109-3644861 [Sphingopyxis sp. MG]
GTGAGTTTGAATGTCAAAGACCCGGAGGCACACCGCCTCGCACAGGCTATCGCGCGGGCGACTGGCCAGAGCATGACCCG
CGTGGTCACGGATGCCTTGCGCGATCGTCTCGCCGCGATCCAGCGCCGCAAGGCCAGGGCCAGCGTGGAGGAACTCCTCG
CGATTGCCGACCGAGCGGCTGCCCATGTGAAGCGCCCCTACGCCGATCATGCCGAACTGTTATACGACGACGCCGGCCTG
CCTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0VTQ5

Antitoxin

Source ID Structure
AlphaFold DB A0A2L0VTM1

References