94740

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2916986..2918448 Replicon chromosome
Accession NZ_CP026381
Organism Sphingopyxis sp. MG

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag C3E99_RS13380 Protein ID WP_104959933.1
Coordinates 2916986..2918233 (-) Length 416 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag C3E99_RS13385 Protein ID WP_104959934.1
Coordinates 2918230..2918448 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3E99_RS13360 2912036..2913448 + 1413 WP_104959562.1 IS4 family transposase -
C3E99_RS13365 2913694..2914581 - 888 WP_104959930.1 DMT family transporter -
C3E99_RS13370 2914591..2915520 - 930 WP_104959931.1 nucleotidyltransferase and HEPN domain-containing protein -
C3E99_RS13375 2915584..2916525 - 942 WP_104959932.1 DUF2493 domain-containing protein -
C3E99_RS13380 2916986..2918233 - 1248 WP_104959933.1 type II toxin-antitoxin system HipA family toxin Toxin
C3E99_RS13385 2918230..2918448 - 219 WP_104959934.1 helix-turn-helix transcriptional regulator Antitoxin
C3E99_RS13390 2918784..2919821 - 1038 WP_104959935.1 toprim domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Transcription regulator, HipB-like

(5-59)


Sequences

Toxin        


Download         Length: 416 a.a.        Molecular weight: 43719.91 Da        Isoelectric Point: 5.1281

>T94740 WP_104959933.1 NZ_CP026381:c2918233-2916986 [Sphingopyxis sp. MG]
MSDALAVYWDDRRVGTLARNAEGTMLFCYDDLWLADPAFRPISASLPRQTGPFSRAATRPFFAGLLPDEEQRAAAARAAG
VSAQNDYALLDALGGDVAGALVIVPEGQAVPAASGTAPDPLTEAALAALLEELPRRPFLVGDEGIRMSLAGAQPKLPVIL
VAGAPALPSPGQPTTHIVKPAMSRFAHSVETEAFAMRLAAAAGLAVAAVEPRRASAIPYLLVERYDRSDAGGTIRRIHQE
DFCQALGIAPEHKYAIEGGPGFAACFDLVRRTCTAPARDILRLLDAAIFNAVVGNADAHGKNFSLLYRDDATVLAPLYDL
MVTAHYPEVATRFAMPIGRANQLDGLDARAWERLATDTGLGAPFVRRRVQALADGIREAAPGIADALAHEGCDPDVLASL
VALVGHRADAIAAAL

Download         Length: 1248 bp

>T94740 NZ_CP026381:c2918233-2916986 [Sphingopyxis sp. MG]
ATGAGCGACGCGCTCGCCGTCTACTGGGACGACCGGCGTGTCGGTACGCTCGCGCGCAACGCCGAGGGCACGATGTTGTT
TTGCTACGATGACCTGTGGCTCGCCGATCCCGCCTTCAGGCCGATTTCGGCCTCGCTCCCCCGCCAGACCGGGCCATTCA
GCCGCGCCGCGACCCGCCCTTTCTTCGCCGGTCTCCTTCCCGATGAAGAACAGCGCGCCGCCGCGGCGCGCGCCGCCGGT
GTCTCGGCCCAGAATGATTATGCGCTGCTCGACGCCCTCGGCGGCGACGTCGCCGGCGCATTGGTCATCGTGCCGGAAGG
GCAGGCGGTACCCGCAGCTTCGGGCACGGCCCCCGACCCGCTGACCGAGGCGGCGCTCGCGGCGCTCCTCGAGGAACTGC
CGCGCCGTCCCTTTCTCGTTGGCGACGAGGGCATACGCATGTCGCTCGCGGGCGCGCAGCCCAAGCTGCCGGTCATTCTC
GTCGCGGGCGCTCCCGCGCTGCCGTCTCCGGGGCAGCCGACCACCCACATCGTCAAGCCCGCCATGTCCCGCTTCGCGCA
CAGCGTCGAAACGGAAGCCTTCGCGATGCGACTGGCCGCCGCCGCCGGTCTCGCCGTGGCGGCGGTCGAGCCGCGCCGCG
CTTCGGCCATCCCCTATCTTCTCGTCGAGCGATACGACCGCAGCGACGCTGGGGGCACGATCCGGCGTATCCACCAGGAG
GATTTCTGCCAGGCGCTCGGCATCGCGCCCGAACATAAATATGCCATCGAGGGCGGGCCCGGCTTTGCCGCCTGCTTCGA
TCTCGTTCGCCGCACCTGCACTGCTCCGGCCCGCGACATCCTGCGCCTGCTCGATGCGGCCATATTCAACGCAGTGGTCG
GCAACGCCGATGCGCATGGCAAGAATTTCAGCCTCCTGTACCGCGACGATGCGACCGTCCTCGCTCCGCTCTACGATCTC
ATGGTCACGGCCCATTATCCCGAGGTCGCCACCCGCTTCGCGATGCCGATCGGCCGCGCCAACCAGCTCGACGGTCTCGA
TGCGCGCGCATGGGAACGCCTTGCCACCGACACAGGGCTCGGCGCCCCCTTCGTCCGCCGCCGTGTCCAGGCCCTCGCTG
ACGGCATCCGCGAGGCCGCACCGGGCATCGCCGACGCGCTCGCTCACGAAGGCTGCGATCCCGATGTTCTCGCGTCGCTC
GTGGCGCTCGTCGGACACCGGGCCGATGCCATAGCGGCCGCGCTCTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7518.66 Da        Isoelectric Point: 7.0089

>AT94740 WP_104959934.1 NZ_CP026381:c2918448-2918230 [Sphingopyxis sp. MG]
MDITTLGQLVRRVRKQAGLRQDELAGAAGVGIRFIVDLESGKSTLQIGKVLHVLDTLGIAATFSAPGEDSVG

Download         Length: 219 bp

>AT94740 NZ_CP026381:c2918448-2918230 [Sphingopyxis sp. MG]
ATGGATATCACGACCCTAGGGCAATTGGTGCGCCGTGTGCGCAAACAGGCTGGTCTTCGCCAGGATGAACTCGCTGGCGC
GGCGGGCGTGGGTATACGTTTCATCGTCGATCTCGAAAGCGGCAAGTCCACGCTGCAGATCGGCAAGGTGCTGCATGTCC
TCGATACGCTGGGTATCGCCGCTACCTTCTCGGCGCCCGGAGAGGACAGCGTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References