Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-couple_hipB
Location 1393834..1394441 Replicon chromosome
Accession NZ_CP026381
Organism Sphingopyxis sp. MG

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C3E99_RS06410 Protein ID WP_067110044.1
Coordinates 1394193..1394441 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag C3E99_RS06405 Protein ID WP_067184054.1
Coordinates 1393834..1394181 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3E99_RS06380 1389746..1390555 - 810 WP_067184063.1 phosphoadenylyl-sulfate reductase -
C3E99_RS06385 1390617..1391042 - 426 WP_067184061.1 DUF934 domain-containing protein -
C3E99_RS06390 1391035..1392669 - 1635 WP_067184059.1 nitrite/sulfite reductase -
C3E99_RS06395 1392671..1392967 - 297 WP_067110003.1 DUF2849 domain-containing protein -
C3E99_RS06400 1392955..1393752 - 798 WP_067184056.1 uroporphyrinogen-III C-methyltransferase -
C3E99_RS06405 1393834..1394181 - 348 WP_067184054.1 helix-turn-helix transcriptional regulator Antitoxin
C3E99_RS06410 1394193..1394441 - 249 WP_067110044.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C3E99_RS06415 1394496..1395941 - 1446 WP_076075683.1 succinylglutamate-semialdehyde dehydrogenase -
C3E99_RS06420 1395997..1396959 + 963 WP_083675217.1 alpha/beta hydrolase -
C3E99_RS06425 1397088..1398155 + 1068 WP_104960333.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1385637..1394447 8810


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-80)

Antitoxin

Cro/C1-type helix-turn-helix domain

(59-112)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9011.47 Da        Isoelectric Point: 10.8825

>T94739 WP_067110044.1 NZ_CP026381:c1394441-1394193 [Sphingopyxis sp. MG]
VKPIAYTRSAIRTLGRMPANTARLIRSKIEQYASDPASLANNVKALKGRDAVRLRVGDWRVIMEDGVVVAVLEIGSRGSI
YE

Download         Length: 249 bp

>T94739 NZ_CP026381:c1394441-1394193 [Sphingopyxis sp. MG]
GTGAAGCCCATCGCCTACACCCGGTCCGCCATCAGGACGCTGGGCCGTATGCCGGCGAATACGGCGCGATTGATCCGGTC
GAAGATCGAACAATATGCAAGCGATCCCGCATCGCTGGCGAACAATGTCAAAGCCTTGAAGGGGCGCGACGCCGTCCGCC
TTCGCGTCGGCGACTGGCGTGTGATCATGGAAGACGGGGTCGTTGTCGCGGTTCTGGAAATCGGCTCGCGCGGCAGCATC
TATGAGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12974.59 Da        Isoelectric Point: 4.8192

>AT94739 WP_067184054.1 NZ_CP026381:c1394181-1393834 [Sphingopyxis sp. MG]
VNKMVTIPQDEYDRLREAAEELVDLRAYDRAKARLDAGEDELVPAEYADRILDGENPLRVWRDLRGWTQQGLAQASGVNR
VQIADIESGRKRGSVETIARLARALRVGMEDLVRG

Download         Length: 348 bp

>AT94739 NZ_CP026381:c1394181-1393834 [Sphingopyxis sp. MG]
GTGAACAAGATGGTGACGATCCCGCAAGACGAATATGACCGCCTTCGCGAAGCGGCGGAGGAGCTAGTCGACCTTCGCGC
CTATGATCGGGCGAAGGCGCGTCTTGATGCGGGCGAAGACGAGCTGGTTCCCGCCGAATATGCCGATCGCATCCTTGACG
GCGAAAATCCGCTTCGCGTCTGGCGCGATCTGCGCGGATGGACCCAGCAGGGCCTGGCACAGGCGTCGGGCGTCAACCGG
GTCCAGATCGCCGATATCGAATCGGGCCGAAAGCGGGGATCGGTGGAAACCATAGCGCGGCTGGCACGCGCGCTGCGCGT
CGGAATGGAGGATCTGGTGCGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References