Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3591402..3592065 Replicon chromosome
Accession NZ_CP026378
Organism Mixta calida strain DSM 22759

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag C2E16_RS17130 Protein ID WP_052133863.1
Coordinates 3591402..3591803 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag C2E16_RS17135 Protein ID WP_038624329.1
Coordinates 3591787..3592065 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2E16_RS17110 3587369..3589099 - 1731 WP_038624337.1 single-stranded-DNA-specific exonuclease RecJ -
C2E16_RS17115 3589106..3589810 - 705 WP_038624335.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C2E16_RS17120 3589836..3590729 - 894 WP_038624333.1 site-specific tyrosine recombinase XerD -
C2E16_RS17125 3590837..3591355 + 519 WP_038629888.1 flavodoxin FldB -
C2E16_RS17130 3591402..3591803 - 402 WP_052133863.1 hypothetical protein Toxin
C2E16_RS17135 3591787..3592065 - 279 WP_038624329.1 FAD assembly factor SdhE Antitoxin
C2E16_RS17140 3592292..3593275 + 984 WP_038624327.1 tRNA-modifying protein YgfZ -
C2E16_RS17145 3593317..3593976 - 660 WP_038624325.1 hemolysin III family protein -
C2E16_RS17150 3594197..3594928 + 732 WP_038624323.1 MurR/RpiR family transcriptional regulator -
C2E16_RS17155 3595143..3596579 + 1437 WP_084970471.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-128)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15813.86 Da        Isoelectric Point: 12.0944

>T94738 WP_052133863.1 NZ_CP026378:c3591803-3591402 [Mixta calida]
VRWQSDLSPSARAQQITCLLYSPLVFGLLLLPWPPSLAPLMMVLLLLMLGELWRRLHLQRRFSGRLTAEESRIWRWRQRD
YQVMRPPFILPFGILLTLRTPQGTRLSLWLMRDSMPEANWRALRRLFKGYEPG

Download         Length: 402 bp

>T94738 NZ_CP026378:c3591803-3591402 [Mixta calida]
GTGCGGTGGCAATCTGATCTCTCCCCGTCGGCGCGGGCGCAGCAGATAACCTGCCTGCTCTATAGCCCGCTCGTCTTCGG
ATTGCTGTTGTTGCCCTGGCCGCCGTCGCTGGCGCCGTTGATGATGGTGCTGCTGCTGCTAATGCTCGGCGAACTGTGGC
GACGTCTGCATCTACAACGTCGCTTCAGCGGCCGCTTAACGGCGGAGGAAAGCCGCATCTGGCGCTGGCGACAGCGGGAT
TATCAGGTGATGCGGCCGCCGTTTATTCTGCCGTTTGGCATACTGCTTACGCTGCGCACGCCGCAGGGGACACGCCTGTC
ATTGTGGCTGATGCGGGACAGCATGCCGGAAGCGAACTGGCGCGCGCTGCGTCGCCTGTTTAAGGGATATGAGCCCGGCT
AA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10809.39 Da        Isoelectric Point: 5.1340

>AT94738 WP_038624329.1 NZ_CP026378:c3592065-3591787 [Mixta calida]
MDINDKSRIHWACRRGMLELDIAIMPFFKYEYDSLSDEDKALFIRLLKSDDPDLFNWLMNHGEPADAELKRMVQLIQTRN
QQRGPERGAVAI

Download         Length: 279 bp

>AT94738 NZ_CP026378:c3592065-3591787 [Mixta calida]
ATGGATATCAACGATAAATCCCGTATTCACTGGGCCTGCCGCCGCGGCATGCTGGAGCTGGATATCGCCATTATGCCTTT
CTTTAAATATGAATATGATTCGCTGAGCGATGAAGATAAGGCGCTGTTTATTCGTCTGCTGAAAAGCGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGCGAGCCGGCCGATGCCGAGCTGAAACGTATGGTGCAGCTGATTCAGACGCGCAAC
CAGCAGCGTGGCCCGGAACGTGGTGCGGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References