Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3465737..3466380 Replicon chromosome
Accession NZ_CP026378
Organism Mixta calida strain DSM 22759

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag C2E16_RS16565 Protein ID WP_038624510.1
Coordinates 3465964..3466380 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag C2E16_RS16560 Protein ID WP_084970331.1
Coordinates 3465737..3465967 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2E16_RS16545 3461038..3461925 + 888 WP_084970329.1 dihydrodipicolinate synthase family protein -
C2E16_RS16550 3461996..3462337 - 342 WP_038624517.1 alkylphosphonate utilization protein -
C2E16_RS16555 3462626..3465193 + 2568 WP_174705333.1 DNA mismatch repair protein MutS -
C2E16_RS16560 3465737..3465967 + 231 WP_084970331.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C2E16_RS16565 3465964..3466380 + 417 WP_038624510.1 type II toxin-antitoxin system VapC family toxin Toxin
C2E16_RS16570 3466569..3467471 - 903 WP_038629895.1 LysR family transcriptional regulator -
C2E16_RS16575 3467595..3468986 + 1392 WP_038624508.1 MFS transporter -
C2E16_RS20625 3469386..3469826 + 441 WP_133052060.1 hypothetical protein -
C2E16_RS20900 3470048..3470203 - 156 WP_156462399.1 hypothetical protein -
C2E16_RS16590 3470265..3470681 - 417 WP_084970333.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14921.26 Da        Isoelectric Point: 6.8621

>T94737 WP_038624510.1 NZ_CP026378:3465964-3466380 [Mixta calida]
VIKTYMLDTNICSFIMREQPEAVIKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGLLVEAFCARLDAILSWDRA
AVDATTEIKAALTAAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFEHVPGLVLEDWAN

Download         Length: 417 bp

>T94737 NZ_CP026378:3465964-3466380 [Mixta calida]
GTGATCAAGACCTATATGCTGGACACCAACATTTGCTCCTTCATCATGCGTGAGCAGCCGGAAGCTGTCATTAAACGGCT
GGAACAGGCAGTACTGCGCAATCATCGTATCGTGGTTTCGGCCATCACCTATGCCGAGATGCGTTTCGGTGCGATCGGAA
AGAAGGCATCTCCCCGCCATGGCTTGCTCGTCGAAGCTTTCTGCGCCCGTCTCGATGCAATCCTCTCCTGGGATCGCGCC
GCGGTGGACGCAACCACAGAGATTAAGGCCGCGCTGACTGCGGCCGGGACGCCAATCGGTCCGAACGACACGGCGATTGC
CGGGCATGCCATCGCCGCCGGCGCCGTACTGGTGACGAACAACGTGCGAGAGTTTGAGCATGTGCCTGGGCTGGTTCTGG
AAGACTGGGCTAACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8685.75 Da        Isoelectric Point: 4.4563

>AT94737 WP_084970331.1 NZ_CP026378:3465737-3465967 [Mixta calida]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIIREGDSIILRPVRPTWGSFTQLEKADSDFMAERGDVVSDEGRFDL

Download         Length: 231 bp

>AT94737 NZ_CP026378:3465737-3465967 [Mixta calida]
ATGAGAACCGTATCAATATTCAAAAACGGCAATAATCGCGCTATCCGTCTGCCCCGAGACCTGGATTTTGAGGGAGTGAG
CGAACTGGAGATCATCCGGGAAGGTGACAGCATTATCCTTCGTCCCGTTCGCCCAACATGGGGTTCGTTTACTCAGCTCG
AAAAAGCCGATTCAGACTTTATGGCCGAGCGTGGGGACGTCGTCAGCGATGAAGGACGGTTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References