Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3267010..3267644 Replicon chromosome
Accession NZ_CP026378
Organism Mixta calida strain DSM 22759

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C2E16_RS15540 Protein ID WP_084971120.1
Coordinates 3267010..3267414 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C2E16_RS15545 Protein ID WP_038624739.1
Coordinates 3267414..3267644 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2E16_RS15520 3262091..3262696 + 606 WP_084971118.1 tellurite resistance methyltransferase TehB -
C2E16_RS15525 3262697..3264850 - 2154 WP_052134006.1 sensor domain-containing phosphodiesterase -
C2E16_RS15530 3265174..3265359 + 186 WP_038624745.1 DUF2633 family protein -
C2E16_RS15535 3265472..3266899 + 1428 WP_038624743.1 magnesium transporter -
C2E16_RS15540 3267010..3267414 - 405 WP_084971120.1 tRNA(fMet)-specific endonuclease VapC Toxin
C2E16_RS15545 3267414..3267644 - 231 WP_038624739.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C2E16_RS15550 3267932..3269512 - 1581 WP_038624737.1 glutamine-hydrolyzing GMP synthase -
C2E16_RS15555 3269584..3271050 - 1467 WP_038624735.1 IMP dehydrogenase -
C2E16_RS15560 3271220..3272590 + 1371 WP_038624733.1 exodeoxyribonuclease VII large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14972.27 Da        Isoelectric Point: 7.8710

>T94736 WP_084971120.1 NZ_CP026378:c3267414-3267010 [Mixta calida]
MLKYMLDTNICIYTIKNKPPTVRTAFNQRYGQLCVSSVTLMELIYEAEKSASPEKNLRVVEGFIARLEVLNYSNEAAIHT
GQIRAELAKAGTPVGPYDSMIAAHARSLGLILVTNNTHEFVRISGLRLEDWSVN

Download         Length: 405 bp

>T94736 NZ_CP026378:c3267414-3267010 [Mixta calida]
ATGCTCAAATATATGTTGGATACCAACATCTGTATTTATACCATTAAAAACAAGCCTCCGACTGTGCGCACCGCTTTTAA
TCAACGTTATGGACAGCTGTGCGTCAGTTCCGTAACGCTAATGGAACTGATCTACGAAGCGGAGAAATCTGCCAGCCCGG
AAAAAAATCTGCGGGTAGTAGAAGGCTTTATCGCCAGGCTGGAAGTATTAAATTATAGTAACGAGGCTGCAATCCATACG
GGGCAAATTCGTGCGGAGCTGGCGAAAGCGGGGACGCCGGTCGGTCCGTATGACAGTATGATCGCGGCGCATGCCCGATC
GCTGGGGCTGATTCTGGTCACCAATAATACACACGAATTTGTCAGAATCTCCGGGCTGCGCCTGGAGGACTGGAGCGTTA
ATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8585.50 Da        Isoelectric Point: 4.2821

>AT94736 WP_038624739.1 NZ_CP026378:c3267644-3267414 [Mixta calida]
MEKTTVFKNNRSQAVRLPKAVALPDNVSQVEIIAVGRTRIITPAGEGWDSWFDGEDVTSDFMTARDQPDEQERESF

Download         Length: 231 bp

>AT94736 NZ_CP026378:c3267644-3267414 [Mixta calida]
ATGGAAAAGACGACCGTGTTTAAAAACAATCGCAGCCAGGCGGTGCGTTTGCCTAAAGCCGTCGCGCTGCCGGACAATGT
CAGCCAGGTTGAAATTATTGCCGTGGGCCGGACGCGGATAATTACGCCCGCAGGCGAGGGTTGGGATAGCTGGTTTGATG
GAGAGGACGTAACATCAGATTTTATGACGGCACGGGATCAGCCTGATGAACAAGAAAGGGAAAGCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References