Detailed information of TA system TA094733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1301816..1302444
• Replicon: chromosome
• Accession: NZ_CP026377
• Organism: Mixta gaviniae strain DSM 22758

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A2K1QC31
• Locus tag: C2E15_RS05975
• Protein ID: WP_071883698.1
• Coordinates: 1301816..1302034 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: C2E15_RS05980
• Protein ID: WP_104956558.1
• Coordinates: 1302064..1302444 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2E15_RS05945	1297783..1298121	+	339	WP_104956553.1	P-II family nitrogen regulator	-
C2E15_RS05950	1298158..1299441	+	1284	WP_104956554.1	ammonium transporter AmtB	-
C2E15_RS05955	1299496..1300356	-	861	WP_104956555.1	acyl-CoA thioesterase II	-
C2E15_RS05960	1300570..1301130	+	561	WP_104956556.1	YbaY family lipoprotein	-
C2E15_RS05965	1301163..1301471	-	309	WP_104956557.1	MGMT family protein	-
C2E15_RS05975	1301816..1302034	-	219	WP_071883698.1	hemolysin expression modulator Hha	Toxin
C2E15_RS05980	1302064..1302444	-	381	WP_104956558.1	Hha toxicity modulator TomB	Antitoxin
C2E15_RS05985	1302592..1302945	-	354	WP_104956559.1	hypothetical protein	-
C2E15_RS05990	1303293..1303433	-	141	WP_104956560.1	type B 50S ribosomal protein L36	-
C2E15_RS05995	1303443..1303700	-	258	WP_104956561.1	type B 50S ribosomal protein L31	-
C2E15_RS06000	1304184..1307333	-	3150	WP_104956562.1	multidrug efflux RND transporter permease subunit AcrB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8701.16 Da
• Isoelectric Point: 8.8578

>T94733 WP_071883698.1 NZ_CP026377:c1302034-1301816 [Mixta gaviniae]
MTEKIMTKTDYLMRLRRCRSIDTLERVIEKNKYELPDDELAVFYSAADHRLAELTMNKLYDKVPVSVWKYVR

Nucleotide

• Length: 219 bp

>T94733 NZ_CP026377:c1302034-1301816 [Mixta gaviniae]
ATGACAGAAAAAATTATGACCAAAACTGACTATCTGATGCGCTTAAGACGTTGCAGATCAATCGATACGCTTGAGCGGGT
GATCGAAAAGAATAAATATGAATTGCCTGATGATGAACTGGCTGTTTTTTATTCTGCGGCCGATCATCGGCTGGCGGAAT
TAACCATGAATAAGCTGTACGATAAAGTACCGGTTTCGGTGTGGAAATACGTTCGTTGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14755.38 Da
• Isoelectric Point: 4.3024

>AT94733 WP_104956558.1 NZ_CP026377:c1302444-1302064 [Mixta gaviniae]
MDEYSPKRHDIAQLNFLCENLYDESMATLGDSHHGWVNDPTSATNLQLNELIEHIASFTMNYKIKHAEDEDLIVQIDDYL
DDTFMLFSNYGINVQDLQRWQRSARRLFNLFAEECAQLPLQPSHSF

Nucleotide

• Length: 381 bp

>AT94733 NZ_CP026377:c1302444-1302064 [Mixta gaviniae]
ATGGACGAATATTCACCGAAACGGCATGATATTGCCCAGCTCAATTTCTTGTGTGAAAATCTGTACGACGAAAGTATGGC
CACGCTGGGTGACAGCCACCATGGCTGGGTCAACGATCCTACATCTGCGACCAACTTACAGCTGAATGAGCTGATTGAAC
ATATTGCTTCATTCACTATGAATTACAAAATAAAACATGCTGAAGATGAGGATCTCATCGTCCAGATCGATGACTACCTC
GACGATACCTTTATGTTATTCAGTAATTACGGCATTAATGTTCAGGATCTGCAACGTTGGCAACGTTCCGCCCGACGTTT
GTTTAATCTTTTCGCGGAAGAGTGCGCTCAGCTTCCTTTACAGCCAAGCCATTCATTTTAA

Structures

Toxin

• AlphaFold DB: A0A2K1QC31