Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 27720..28245 | Replicon | plasmid pA708-3 |
Accession | NZ_CP026371 | ||
Organism | Klebsiella quasipneumoniae strain A708 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | W8UQV6 |
Locus tag | C2767_RS29470 | Protein ID | WP_001568026.1 |
Coordinates | 27940..28245 (+) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | W8V2V6 |
Locus tag | C2767_RS29465 | Protein ID | WP_001568025.1 |
Coordinates | 27720..27938 (+) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C2767_RS29415 | 23576..24352 | + | 777 | WP_060617172.1 | DUF2971 domain-containing protein | - |
C2767_RS29420 | 24488..24742 | - | 255 | WP_009653916.1 | hypothetical protein | - |
C2767_RS29425 | 24818..25075 | - | 258 | WP_004098928.1 | hypothetical protein | - |
C2767_RS29430 | 25124..25327 | - | 204 | WP_004098931.1 | hemolysin expression modulator Hha | - |
C2767_RS29435 | 25361..25729 | - | 369 | WP_101740016.1 | hypothetical protein | - |
C2767_RS29440 | 25773..26267 | - | 495 | WP_049106297.1 | hypothetical protein | - |
C2767_RS29445 | 26298..26864 | - | 567 | WP_151114795.1 | hypothetical protein | - |
C2767_RS29450 | 26861..27124 | - | 264 | WP_013023778.1 | hypothetical protein | - |
C2767_RS29465 | 27720..27938 | + | 219 | WP_001568025.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
C2767_RS29470 | 27940..28245 | + | 306 | WP_001568026.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
C2767_RS29475 | 28414..28809 | + | 396 | WP_017899885.1 | hypothetical protein | - |
C2767_RS29480 | 28836..29159 | + | 324 | WP_022644730.1 | hypothetical protein | - |
C2767_RS29485 | 29156..30172 | + | 1017 | WP_020315256.1 | hypothetical protein | - |
C2767_RS29490 | 30370..31164 | + | 795 | WP_004197635.1 | site-specific integrase | - |
C2767_RS30590 | 31251..31448 | - | 198 | WP_158236951.1 | hypothetical protein | - |
C2767_RS29495 | 31604..31783 | - | 180 | WP_006788217.1 | hypothetical protein | - |
C2767_RS29500 | 31903..32529 | - | 627 | WP_004197649.1 | ParA family plasmid-partitioning AAA ATPase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | - | 1..133085 | 133085 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11645.32 Da Isoelectric Point: 5.6919
>T94732 WP_001568026.1 NZ_CP026371:27940-28245 [Klebsiella quasipneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T94732 NZ_CP026371:27940-28245 [Klebsiella quasipneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8392.34 Da Isoelectric Point: 4.7405
>AT94732 WP_001568025.1 NZ_CP026371:27720-27938 [Klebsiella quasipneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT94732 NZ_CP026371:27720-27938 [Klebsiella quasipneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGTGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
ATGAAGCAGCGCATCACTGTCACCATAGACAGTGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A514EZN1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4ZZP8 |