Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4282675..4283294 Replicon chromosome
Accession NZ_CP026368
Organism Klebsiella quasipneumoniae strain A708

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag C2767_RS21205 Protein ID WP_002892050.1
Coordinates 4283076..4283294 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag C2767_RS21200 Protein ID WP_002892066.1
Coordinates 4282675..4283049 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2767_RS21190 4277828..4279021 + 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C2767_RS21195 4279044..4282190 + 3147 WP_023288644.1 multidrug efflux RND transporter permease subunit -
C2767_RS21200 4282675..4283049 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
C2767_RS21205 4283076..4283294 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
C2767_RS21210 4283453..4284019 + 567 WP_023288643.1 maltose O-acetyltransferase -
C2767_RS30490 4283991..4284122 - 132 WP_181573375.1 hypothetical protein -
C2767_RS21215 4284156..4284626 + 471 WP_023288642.1 YlaC family protein -
C2767_RS21220 4284595..4286052 - 1458 WP_112201830.1 PLP-dependent aminotransferase family protein -
C2767_RS21225 4286153..4286851 + 699 WP_112201831.1 GNAT family N-acetyltransferase -
C2767_RS21230 4286848..4286988 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
C2767_RS21235 4286988..4287251 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T94727 WP_002892050.1 NZ_CP026368:4283076-4283294 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T94727 NZ_CP026368:4283076-4283294 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGCCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT94727 WP_002892066.1 NZ_CP026368:4282675-4283049 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT94727 NZ_CP026368:4282675-4283049 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGATACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References