Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 808333..808990 Replicon chromosome
Accession NZ_CP026368
Organism Klebsiella quasipneumoniae strain A708

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag C2767_RS04055 Protein ID WP_023290968.1
Coordinates 808580..808990 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag C2767_RS04050 Protein ID WP_002916312.1
Coordinates 808333..808599 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2767_RS04025 803483..804916 - 1434 WP_112201234.1 6-phospho-beta-glucosidase -
C2767_RS04030 805035..805763 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
C2767_RS04035 805814..806125 + 312 WP_080820267.1 N(4)-acetylcytidine aminohydrolase -
C2767_RS04040 806289..806948 + 660 WP_008806429.1 hemolysin III family protein -
C2767_RS04045 807104..808087 - 984 WP_112201235.1 tRNA-modifying protein YgfZ -
C2767_RS04050 808333..808599 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
C2767_RS04055 808580..808990 + 411 WP_023290968.1 protein YgfX Toxin
C2767_RS04060 808997..809518 - 522 WP_004205324.1 flavodoxin FldB -
C2767_RS04065 809619..810515 + 897 WP_044524682.1 site-specific tyrosine recombinase XerD -
C2767_RS04070 810538..811251 + 714 WP_049014195.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C2767_RS04075 811257..812990 + 1734 WP_032454029.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T94717 WP_023290968.1 NZ_CP026368:808580-808990 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T94717 NZ_CP026368:808580-808990 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATCCCGGAGAGTGGCGGGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT94717 WP_002916312.1 NZ_CP026368:808333-808599 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT94717 NZ_CP026368:808333-808599 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References