Detailed information of TA system TA094715

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-HicB
• Location: 423..1076
• Replicon: chromosome
• Accession: NZ_CP026363
• Organism: Brevibacillus agri strain DSM 6348

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: BA6348_RS00010
• Protein ID: WP_129552141.1
• Coordinates: 423..773 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: BA6348_RS00015
• Protein ID: WP_129552142.1
• Coordinates: 777..1076 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BA6348_RS00005	3..294	-	292	Protein_1	transposase zinc-binding domain-containing protein	-
BA6348_RS00010	423..773	-	351	WP_129552141.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BA6348_RS00015	777..1076	-	300	WP_129552142.1	CopG family ribbon-helix-helix protein	Antitoxin
BA6348_RS00020	1254..2455	-	1202	Protein_4	alanine racemase	-
BA6348_RS00025	2458..2898	-	441	WP_005830198.1	hypothetical protein	-
BA6348_RS00030	3179..4300	-	1122	WP_122953518.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (1-46)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13124.20 Da
• Isoelectric Point: 6.4752

>T94715 WP_129552141.1 NZ_CP026363:c773-423 [Brevibacillus agri]
VIVKRGDVFFADLSPVVGSEQGGVRPVLVIRTTLEIDLVRRSSSPPLRPKIQKAKLPTHVEIDAKTYGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVNESLQISLGLIDF

Nucleotide

• Length: 351 bp

>T94715 NZ_CP026363:c773-423 [Brevibacillus agri]
GTGATTGTCAAACGTGGCGATGTATTTTTCGCGGACCTGTCACCGGTCGTTGGCTCTGAGCAAGGAGGCGTGCGGCCTGT
TTTAGTCATCAGAACGACATTGGAAATCGATTTAGTCCGACGGTCATCGTCGCCGCCATTACGGCCCAAAATTCAGAAGG
CAAAACTGCCTACGCATGTGGAAATTGACGCAAAAACATATGGATTTGATCGTGACTCCGTCATTTTGTTGGAACAAATA
CGAACCATTGACAAACAGAGGCTGACTGATAAGATTACCCATCTTGACGACGAGATGATGGATCGGGTCAATGAGTCTTT
GCAAATCAGCTTGGGACTCATTGATTTCTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11436.35 Da
• Isoelectric Point: 9.9706

>AT94715 WP_129552142.1 NZ_CP026363:c1076-777 [Brevibacillus agri]
MVGVDLSCRSQNTKRIMISLPQHLLQEVDGVIQKEKSNRSEFIRQAMHLYLKERKKRTIRETMQKGYMEMAKINLKMASE
AFGAEEEADHTLVRLVSGV

Nucleotide

• Length: 300 bp

>AT94715 NZ_CP026363:c1076-777 [Brevibacillus agri]
ATGGTTGGAGTGGATTTGTCTTGTCGAAGTCAAAACACGAAACGCATCATGATCAGTTTGCCGCAACACTTGCTACAAGA
AGTGGATGGCGTCATTCAAAAGGAGAAATCCAATCGCAGCGAGTTCATTCGCCAGGCGATGCATTTGTATTTGAAGGAGC
GTAAAAAACGTACGATCCGCGAGACAATGCAAAAAGGGTATATGGAGATGGCGAAGATTAATCTGAAAATGGCATCGGAG
GCTTTTGGCGCTGAAGAAGAGGCTGACCATACTCTTGTCCGCTTAGTTAGCGGGGTGTGA