Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 2162647..2163563 Replicon chromosome
Accession NZ_CP026362
Organism Bacillus vallismortis strain DSM 11031

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A410WII6
Locus tag BV11031_RS11640 Protein ID WP_010330435.1
Coordinates 2162647..2163393 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A5D4N4Z5
Locus tag BV11031_RS11645 Protein ID WP_010330434.1
Coordinates 2163393..2163563 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV11031_RS11615 2157778..2157909 - 132 WP_128568251.1 hypothetical protein -
BV11031_RS11620 2157981..2158931 - 951 WP_010330438.1 ring-cleaving dioxygenase -
BV11031_RS11625 2159316..2160632 + 1317 WP_010330437.1 serine/threonine exchanger -
BV11031_RS11630 2160906..2161523 + 618 WP_003218470.1 DUF47 domain-containing protein -
BV11031_RS11635 2161536..2162537 + 1002 WP_010330436.1 inorganic phosphate transporter family protein -
BV11031_RS11640 2162647..2163393 + 747 WP_010330435.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
BV11031_RS11645 2163393..2163563 + 171 WP_010330434.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
BV11031_RS11650 2163648..2163785 + 138 WP_121642401.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
BV11031_RS11655 2163817..2164710 - 894 WP_010330433.1 N-acetylmuramoyl-L-alanine amidase -
BV11031_RS11660 2164723..2164986 - 264 WP_010330432.1 phage holin -
BV11031_RS11665 2165002..2165271 - 270 WP_010330431.1 hemolysin XhlA family protein -
BV11031_RS11670 2165324..2166163 - 840 WP_010330430.1 hypothetical protein -
BV11031_RS11675 2166207..2166371 - 165 WP_010330429.1 XkdX family protein -
BV11031_RS11680 2166368..2166697 - 330 WP_010330428.1 XkdW family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2154640..2201664 47024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 28968.43 Da        Isoelectric Point: 4.4877

>T94713 WP_010330435.1 NZ_CP026362:2162647-2163393 [Bacillus vallismortis]
MLLFFQIMVWCIMAGLGLYVYATWRFEAKVKEKMPAIGKTWYLLFVLGAMIYWTYKPSSLFDDWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNVTASL
CHYSTQADKDRLTEHMDNPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T94713 NZ_CP026362:2162647-2163393 [Bacillus vallismortis]
ATGCTTTTATTCTTTCAGATCATGGTCTGGTGCATCATGGCCGGATTAGGCTTGTACGTTTACGCCACGTGGCGTTTCGA
AGCGAAAGTCAAAGAAAAAATGCCCGCCATCGGGAAAACATGGTACTTGCTGTTTGTTTTGGGTGCTATGATATACTGGA
CATATAAGCCCTCTTCCCTGTTTGACGACTGGGAACGGTATCTCATTGTCGCCGTCAGTTTCGCTTTAATTGACGCTTTC
ATCTTCTTAAGTGCGTACGTCAAAAAACTGGCCGGCAGCGAACTGGAAACAGACACAAGAGAAATCCTCGAAGAAAACAA
CGAAATGCTTCACATGTATCTCGATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCACGTTTATTATG
GAAGTATAGATGCATATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCAGATAAAATGAATGTAACGGCCTCCCTC
TGTCACTATTCAACACAGGCCGACAAGGACCGATTAACTGAGCATATGGACAATCCCGCGGACGTGCAAACACGGCTCGA
TCGAAAAGATGTGTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAAAGCTACGTCATCA
AGCTGACGTCTGACAGCATTGTCACTGAATTTGATTATTTGCTTTTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6495.49 Da        Isoelectric Point: 10.8401

>AT94713 WP_010330434.1 NZ_CP026362:2163393-2163563 [Bacillus vallismortis]
MERAFQNGCEPRAAKPSKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT94713 NZ_CP026362:2163393-2163563 [Bacillus vallismortis]
ATGGAACGCGCGTTTCAAAACGGGTGCGAGCCCAGAGCGGCAAAACCGTCAAAGATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGTTATCAAGTCAGCCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A410WII6

Antitoxin

Source ID Structure
AlphaFold DB A0A5D4N4Z5

References