Detailed information of TA system TA094571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4533157..4533971
• Replicon: chromosome
• Accession: NZ_CP026358
• Organism: Escherichia coli strain 2A

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: C2R03_RS23420
• Protein ID: WP_001054376.1
• Coordinates: 4533714..4533971 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: C2R03_RS23415
• Protein ID: WP_001309181.1
• Coordinates: 4533157..4533702 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2R03_RS23390	4528848..4530161	-	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-
C2R03_RS23395	4530173..4530451	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
C2R03_RS23400	4530448..4531569	-	1122	WP_000010829.1	M42 family metallopeptidase	-
C2R03_RS24380	4531814..4531930	-	117	Protein_4264	VOC family protein	-
C2R03_RS23405	4531968..4532186	-	219	Protein_4265	hypothetical protein	-
C2R03_RS23410	4532355..4533101	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
C2R03_RS23415	4533157..4533702	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
C2R03_RS23420	4533714..4533971	-	258	WP_001054376.1	hypothetical protein	Toxin
C2R03_RS23430	4534348..4534593	-	246	Protein_4269	GNAT family N-acetyltransferase	-
C2R03_RS23440	4534709..4535949	+	1241	Protein_4270	helicase YjhR	-
C2R03_RS23445	4536532..4537512	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
C2R03_RS23450	4537577..4538683	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T94571 WP_001054376.1 NZ_CP026358:c4533971-4533714 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T94571 NZ_CP026358:c4533971-4533714 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT94571 WP_001309181.1 NZ_CP026358:c4533702-4533157 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT94571 NZ_CP026358:c4533702-4533157 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8