Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) vapBC/RHH-PIN
Location 1347608..1348295 Replicon chromosome
Accession NC_002754
Organism Sulfolobus solfataricus P2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SSO_RS07285 Protein ID WP_080514962.1
Coordinates 1347608..1347997 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SSO_RS07290 Protein ID WP_009991659.1
Coordinates 1347993..1348295 (-) Length 101 a.a.

Genomic Context

SSO_RS07265SSO_RS07270SSO_RS17025SSO_RS07275SSO_RS07295SSO_RS07310SSO_RS07315SSO_RS07260SSO_RS07280SSO_RS07285SSO_RS07290SSO_RS16235
Location: 1343471..1344444 (974 bp)
Type: Others
Protein ID: Protein_1435
Location: 1344586..1345083 (498 bp)
Type: Others
Protein ID: WP_014511660.1
Location: 1345479..1345624 (146 bp)
Type: Others
Protein ID: Protein_1437
Location: 1345806..1346141 (336 bp)
Type: Others
Protein ID: Protein_1438
Location: 1348773..1349345 (573 bp)
Type: Others
Protein ID: WP_010923431.1
Location: 1350749..1351292 (544 bp)
Type: Others
Protein ID: Protein_1444
Location: 1351270..1352527 (1258 bp)
Type: Others
Protein ID: Protein_1445
Location: 1343008..1343346 (339 bp)
Type: Others
Protein ID: WP_010923427.1
Location: 1346285..1347400 (1116 bp)
Type: Others
Protein ID: WP_009991657.1
Location: 1347608..1347997 (390 bp)
Type: Toxin
Protein ID: WP_080514962.1
Location: 1347993..1348295 (303 bp)
Type: Antitoxin
Protein ID: WP_009991659.1
Location: 1349754..1350421 (668 bp)
Type: Others
Protein ID: Protein_1443
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SSO_RS07260 (SSO1486)1343008..1343346-339WP_010923427.1hypothetical protein-
SSO_RS07265 (SSO1487)1343471..1344444+974Protein_1435IS5 family transposase-
SSO_RS07270 (SSO1489)1344586..1345083+498WP_014511660.1hypothetical protein-
SSO_RS170251345479..1345624+146Protein_1437IS630 family transposase-
SSO_RS07275 (SSO1490)1345806..1346141+336Protein_1438transposase-
SSO_RS07280 (SSO1491)1346285..1347400-1116WP_009991657.1hypothetical protein-
SSO_RS07285 (SSO1493)1347608..1347997-390WP_080514962.1type II toxin-antitoxin system VapC family toxinToxin
SSO_RS07290 (SSO1494)1347993..1348295-303WP_009991659.1hypothetical proteinAntitoxin
SSO_RS07295 (SSO1495)1348773..1349345+573WP_010923431.1metallophosphoesterase-
SSO_RS162351349754..1350421-668Protein_1443ISNCY family transposase-
SSO_RS073101350749..1351292+544Protein_1444IS607 family transposase-
SSO_RS07315 (SSO1498)1351270..1352527+1258Protein_1445transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--1312127..134614134014
-insideIScluster/Tn--1333044..135247219428


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(1-122)

Antitoxin

Putative antitoxin VapB3-like

(28-100)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14458.99 Da        Isoelectric Point: 6.4091

>T945 WP_080514962.1 NC_002754:c1347997-1347608 [Saccharolobus solfataricus P2]
IDASVLAKFVTKEKGWEKIREILKDAETLDFALVEVSNVVWKKAVLTGELTGKDVIKAITIVKEYLPQLLTVNKSIDLIE
RAIEISVNEKITVYDSLYIALAECKGSKLVTGDKKQYDVAKKYVISELI

Download         Length: 390 bp

>T945 NC_002754:c1347997-1347608 [Saccharolobus solfataricus P2]
ATTGACGCATCTGTCCTAGCTAAATTTGTAACTAAGGAGAAAGGATGGGAGAAGATTAGAGAGATTTTGAAAGACGCTGA
GACATTAGACTTCGCATTAGTGGAAGTATCTAACGTAGTATGGAAGAAAGCTGTATTAACTGGGGAATTAACTGGGAAAG
ATGTAATTAAGGCAATTACTATTGTTAAAGAGTATTTACCACAACTGCTTACAGTTAACAAAAGCATTGACTTAATTGAA
AGAGCTATTGAGATTTCCGTTAACGAGAAAATCACAGTATATGATTCACTTTATATTGCACTGGCTGAATGTAAGGGGAG
TAAATTGGTAACGGGGGATAAGAAACAATACGACGTAGCTAAAAAGTACGTCATCTCTGAGCTCATATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 12195.09 Da        Isoelectric Point: 4.8275

>AT945 WP_009991659.1 NC_002754:c1348295-1347993 [Saccharolobus solfataricus P2]
MVIKNATILIYVPEIETFIFPVYVYYNMKTVYSLRLDKELREEMEKYNVKWNEEIESFIRKRIEELKKEEILKKINEILQ
TMPETKSNSADLVREDRDNN

Download         Length: 303 bp

>AT945 NC_002754:c1348295-1347993 [Saccharolobus solfataricus P2]
ATGGTAATAAAGAATGCTACAATTTTAATCTATGTACCAGAGATAGAAACGTTTATATTTCCCGTATACGTGTATTATAA
TATGAAAACCGTATACAGTTTAAGGTTAGATAAGGAATTACGTGAGGAGATGGAGAAATATAACGTCAAGTGGAATGAGG
AGATAGAGAGCTTTATAAGAAAGAGAATTGAGGAATTGAAGAAAGAGGAGATCTTAAAGAAGATTAATGAAATCCTCCAA
ACAATGCCAGAAACTAAGTCAAATAGTGCAGATTTGGTGAGGGAAGATAGGGATAATAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References

(1) Yukari Maezato et al. (2011) VapC6, a ribonucleolytic toxin regulates thermophilicity in the crenarchaeote Sulfolobus solfataricus. RNA (New York, N.Y.) 17(7):1381-92. [PubMed:21622901] experimental

(2) Charlotte R Cooper et al. (2009) Role of vapBC toxin-antitoxin loci in the thermal stress response of Sulfolobus solfataricus. Biochemical Society Transactions 37(Pt 1):123-6. [PubMed:19143615] experimental

(3) Sabrina Tachdjian et al. (2006) Dynamic metabolic adjustments and genome plasticity are implicated in the heat shock response of the extremely thermoacidophilic archaeon Sulfolobus solfataricus. Journal of Bacteriology 188(12):4553-9. [PubMed:16740961] experimental


experimental experimental literature