Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5262031..5262698 Replicon chromosome
Accession NZ_CP026334
Organism Xanthomonas citri pv. glycines strain EB08

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag C2859_RS23895 Protein ID WP_005916679.1
Coordinates 5262282..5262698 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag C2859_RS23890 Protein ID WP_005916676.1
Coordinates 5262031..5262285 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2859_RS23865 5258137..5258346 + 210 WP_108350128.1 RNA 2'-phosphotransferase -
C2859_RS23870 5258529..5259794 + 1266 WP_016849472.1 cardiolipin synthase B -
C2859_RS23875 5259820..5260347 - 528 WP_005916668.1 hypothetical protein -
C2859_RS23880 5260586..5260792 + 207 WP_003489327.1 hypothetical protein -
C2859_RS23885 5260779..5261885 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
C2859_RS23890 5262031..5262285 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
C2859_RS23895 5262282..5262698 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
C2859_RS23900 5262820..5263023 - 204 WP_124944764.1 hypothetical protein -
C2859_RS23905 5263105..5263365 - 261 WP_124632112.1 hypothetical protein -
C2859_RS23910 5263622..5265241 + 1620 WP_016849230.1 enterochelin esterase -
C2859_RS23915 5265345..5265743 - 399 WP_004429277.1 DUF2384 domain-containing protein -
C2859_RS23920 5266059..5266490 + 432 WP_016849229.1 hypothetical protein -
C2859_RS23925 5266519..5266845 - 327 Protein_4427 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T93840 WP_005916679.1 NZ_CP026334:5262282-5262698 [Xanthomonas citri pv. glycines]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T93840 NZ_CP026334:5262282-5262698 [Xanthomonas citri pv. glycines]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAAGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT93840 WP_005916676.1 NZ_CP026334:5262031-5262285 [Xanthomonas citri pv. glycines]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT93840 NZ_CP026334:5262031-5262285 [Xanthomonas citri pv. glycines]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References