93837

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 247140..247833 Replicon plasmid pXWY
Accession NZ_CP026333
Organism Pseudomonas sp. XWY-1

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag PRJ_RS28970 Protein ID WP_003151133.1
Coordinates 247456..247833 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag PRJ_RS28965 Protein ID WP_001172026.1
Coordinates 247140..247475 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRJ_RS28940 242551..243069 + 519 WP_177429932.1 hypothetical protein -
PRJ_RS28945 243046..246012 - 2967 WP_104963081.1 Tn3-like element TnAs1 family transposase -
PRJ_RS28950 246083..246424 - 342 WP_025999701.1 hypothetical protein -
PRJ_RS28955 246440..246766 - 327 WP_000091614.1 hypothetical protein -
PRJ_RS28960 246790..247125 - 336 WP_000741275.1 hypothetical protein -
PRJ_RS28965 247140..247475 - 336 WP_001172026.1 helix-turn-helix domain-containing protein Antitoxin
PRJ_RS28970 247456..247833 - 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PRJ_RS28975 248025..248627 + 603 WP_010465829.1 recombinase family protein -
PRJ_RS28980 248611..251640 + 3030 WP_010799689.1 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / qacE / sul1 - 1..394537 394537
- inside IScluster/Tn - - 243046..251640 8594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T93837 WP_003151133.1 NZ_CP026333:c247833-247456 [Pseudomonas sp. XWY-1]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

>T93837 NZ_CP026333:c247833-247456 [Pseudomonas sp. XWY-1]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT93837 WP_001172026.1 NZ_CP026333:c247475-247140 [Pseudomonas sp. XWY-1]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp

>AT93837 NZ_CP026333:c247475-247140 [Pseudomonas sp. XWY-1]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References