Detailed information of TA system TA093836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3755212..3756095
• Replicon: chromosome
• Accession: NZ_CP026332
• Organism: Pseudomonas sp. XWY-1

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q88K57
• Locus tag: PRJ_RS17425
• Protein ID: WP_003250527.1
• Coordinates: 3755212..3755649 (-)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: I7C3Q7
• Locus tag: PRJ_RS17430
• Protein ID: WP_003250525.1
• Coordinates: 3755646..3756095 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PRJ_RS17410	3751509..3752738	-	1230	WP_104962077.1	acyl-CoA dehydrogenase	-
PRJ_RS17415	3752879..3753805	+	927	WP_104962078.1	LysR family transcriptional regulator	-
PRJ_RS17420	3754000..3755154	+	1155	WP_104962891.1	aminotransferase class V-fold PLP-dependent enzyme	-
PRJ_RS17425	3755212..3755649	-	438	WP_003250527.1	RES family NAD+ phosphorylase	Toxin
PRJ_RS17430	3755646..3756095	-	450	WP_003250525.1	DUF2384 domain-containing protein	Antitoxin
PRJ_RS17435	3756238..3756891	-	654	WP_014591578.1	oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB	-
PRJ_RS17440	3756995..3757918	+	924	WP_104962079.1	LysR family transcriptional regulator	-
PRJ_RS17445	3757967..3758797	+	831	WP_003250518.1	AraC family transcriptional regulator	-
PRJ_RS17450	3758849..3759433	+	585	WP_104962080.1	LysE family transporter	-
PRJ_RS17455	3759473..3760672	-	1200	WP_104962081.1	sugar transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-138)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (33-91)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15990.29 Da
• Isoelectric Point: 5.6007

>T93836 WP_003250527.1 NZ_CP026332:c3755649-3755212 [Pseudomonas sp. XWY-1]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAQPELTRTLGNRFLDDCSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Nucleotide

• Length: 438 bp

>T93836 NZ_CP026332:c3755649-3755212 [Pseudomonas sp. XWY-1]
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGCGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCATCAGGC
GGGTCGACCGGTGGTGTATGCCGCCACCAGCCCTCCCGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AGGATTTCCCTACCACCATGCGCTTGCTGCGCATCGAACTGCCCGACACGGTTTCCCAGGCGCAGTTGCCCGCTTTGCAG
CCCGGCTGGTCTGCTCAGCCTGAGTTGACCCGTACGCTGGGCAATCGCTTTCTGGATGACTGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACGCCGGACAGCCGCCTGTTCTAG

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16956.46 Da
• Isoelectric Point: 5.7258

>AT93836 WP_003250525.1 NZ_CP026332:c3756095-3755646 [Pseudomonas sp. XWY-1]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Nucleotide

• Length: 450 bp

>AT93836 NZ_CP026332:c3756095-3755646 [Pseudomonas sp. XWY-1]
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTACCACGAGTACCGGGCGCGCCTGCAGGCGCTGCTGGACATTCCCGAGCT
TGCCAGCGACTTCGAAATTCACACCCGCATCACCGATGGTTTTGCCGCCACCTGGTTGGTGAAGCTGACCGAGCGCGGTG
TGCTCACCCCGGTGGAGCGCGACCAGATCATTCCGCTGCGCACCCTCAAATCCCGTATCGAGCGCGACCAACCGCTGACC
GTGGATGAGAGCGATCGGCTGTTCCGCTCGGCCCACATCACCGCCATGGCCGAGGCCGTGTTCGGTGAAGCGGGCAAGGC
CAAACGCTGGCTTTCCAAGCCCAAGGAACGCTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAAGGCACCA
CTCAGGTCGAAGAAATGCTGCTGCAGATTGCCGAGGGCTATGGCCTGTGA

Structures

Toxin

• PDB: 6GW6

Antitoxin

• AlphaFold DB: I7C3Q7