Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 2106014..2106515 Replicon chromosome
Accession NZ_CP026328
Organism Acidithiobacillus caldus strain MTH-04

Toxin (Protein)


Gene name relE Uniprot ID A0A1E7YLR2
Locus tag A5904_RS10405 Protein ID WP_038472225.1
Coordinates 2106014..2106268 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID F9ZRB0
Locus tag A5904_RS10410 Protein ID WP_004868369.1
Coordinates 2106258..2106515 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5904_RS10375 2102766..2103713 + 948 WP_004868365.1 flippase-like domain-containing protein -
A5904_RS10385 2103816..2104118 - 303 WP_014003338.1 hypothetical protein -
A5904_RS10390 2104406..2105161 + 756 WP_014003339.1 hypothetical protein -
A5904_RS10395 2105203..2105406 + 204 WP_004868366.1 hypothetical protein -
A5904_RS10400 2105580..2105841 + 262 Protein_2027 IS66 family transposase -
A5904_RS10405 2106014..2106268 - 255 WP_038472225.1 Txe/YoeB family addiction module toxin Toxin
A5904_RS10410 2106258..2106515 - 258 WP_004868369.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
A5904_RS10420 2106870..2108768 - 1899 WP_038472227.1 RNA polymerase sigma factor RpoD -
A5904_RS10425 2108878..2110638 - 1761 WP_004868371.1 DNA primase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10056.46 Da        Isoelectric Point: 7.3563

>T93831 WP_038472225.1 NZ_CP026328:c2106268-2106014 [Acidithiobacillus caldus]
MPIKFSDPAWEDYLFWQAHDGDTLKRINTLLKDIRRSPFQGIGKPEPLKHNLAGFWSRRIDEEHRLVYAIQEDTILVAQC
RYHY

Download         Length: 255 bp

>T93831 NZ_CP026328:c2106268-2106014 [Acidithiobacillus caldus]
ATGCCGATTAAGTTCTCCGATCCGGCCTGGGAGGACTATCTGTTCTGGCAAGCGCACGATGGGGACACGTTGAAGCGCAT
CAATACCCTCCTGAAGGATATACGGCGATCCCCCTTTCAAGGGATCGGAAAACCCGAACCCCTGAAGCATAACCTGGCCG
GCTTTTGGTCCAGACGCATCGACGAAGAGCATCGCCTGGTCTATGCGATCCAAGAGGACACTATTTTGGTTGCCCAATGC
CGCTACCACTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9372.69 Da        Isoelectric Point: 5.6492

>AT93831 WP_004868369.1 NZ_CP026328:c2106515-2106258 [Acidithiobacillus caldus]
MDAVTYSHTRQHLSEIMNKVTNDRAPILITRQSGEPVVMMSLQDFNALEETAYLMRSPKNAKRLAEAIEQLAAGGGTIRA
LVDAD

Download         Length: 258 bp

>AT93831 NZ_CP026328:c2106515-2106258 [Acidithiobacillus caldus]
ATGGACGCGGTAACCTACAGCCACACCCGACAGCACTTGTCCGAGATCATGAACAAGGTCACCAATGACCGCGCTCCGAT
CCTGATCACGCGCCAATCCGGAGAACCGGTCGTGATGATGTCCCTGCAGGATTTCAACGCCCTGGAAGAAACCGCCTACC
TGATGCGCAGCCCGAAAAACGCGAAGCGACTCGCCGAAGCCATCGAGCAGCTGGCGGCGGGCGGCGGGACGATCAGGGCA
CTGGTGGATGCCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7YLR2

Antitoxin

Source ID Structure
AlphaFold DB A0A1E7YLU8

References