Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 330632..331289 Replicon chromosome
Accession NZ_CP026324
Organism Helicobacter pylori strain 26695-dRdM2

Toxin (Protein)


Gene name VapD Uniprot ID T5D7N9
Locus tag C2842_RS01615 Protein ID WP_000271050.1
Coordinates 330632..330916 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O25085
Locus tag C2842_RS01620 Protein ID WP_001134066.1
Coordinates 330897..331289 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2842_RS01590 325834..326712 + 879 WP_000850703.1 carbon-nitrogen hydrolase family protein -
C2842_RS01595 326725..327606 + 882 WP_001040419.1 polysaccharide deacetylase -
C2842_RS01600 327652..328020 + 369 WP_000337920.1 hypothetical protein -
C2842_RS01605 328020..328985 + 966 WP_001124369.1 GTP-binding protein -
C2842_RS01610 328991..330136 - 1146 WP_001263616.1 YbfB/YjiJ family MFS transporter -
C2842_RS01615 330632..330916 - 285 WP_000271050.1 endoribonuclease VapD Toxin
C2842_RS01620 330897..331289 - 393 WP_001134066.1 hypothetical protein Antitoxin
C2842_RS01635 331898..334135 - 2238 WP_000716253.1 outer membrane beta-barrel protein -
C2842_RS01645 334432..335187 - 756 WP_000934548.1 HugZ family heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11188.74 Da        Isoelectric Point: 4.8896

>T93817 WP_000271050.1 NZ_CP026324:c330916-330632 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

>T93817 NZ_CP026324:c330916-330632 [Helicobacter pylori]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTGGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15304.38 Da        Isoelectric Point: 7.1101

>AT93817 WP_001134066.1 NZ_CP026324:c331289-330897 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRISFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHEIPNIETQQAMRDALNGINLTQIDSLDDFTNELKRENSKGFENVCFSV

Download         Length: 393 bp

>AT93817 NZ_CP026324:c331289-330897 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAATTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGTCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCATGAGATCCCAAACATTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGAATTAATCTCACTCAAATTGATAG
TTTAGATGATTTTACAAACGAGTTAAAAAGAGAAAATAGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3UI3

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y3E322

References