Detailed information of TA system TA093815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1393400..1393949
• Replicon: chromosome
• Accession: NZ_CP026321
• Organism: Vibrio campbellii strain BoB-53

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: C1N50_RS06825
• Protein ID: WP_045369102.1
• Coordinates: 1393400..1393699 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A812FW55
• Locus tag: C1N50_RS06830
• Protein ID: WP_005443875.1
• Coordinates: 1393707..1393949 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1N50_RS06790	1388404..1389255	+	852	WP_103412972.1	IS3 family transposase	-
C1N50_RS06795	1389314..1391074	+	1761	WP_199768351.1	AAA family ATPase	-
C1N50_RS25745	1391097..1391189	+	93	WP_080255278.1	DUF3265 domain-containing protein	-
C1N50_RS06805	1391702..1391794	+	93	WP_199768352.1	DUF3265 domain-containing protein	-
C1N50_RS06810	1391824..1392123	+	300	WP_103412973.1	hypothetical protein	-
C1N50_RS06815	1392161..1393129	-	969	WP_103412956.1	IS30 family transposase	-
C1N50_RS06820	1393160..1393336	+	177	WP_103413772.1	DUF3265 domain-containing protein	-
C1N50_RS06825	1393400..1393699	-	300	WP_045369102.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C1N50_RS06830	1393707..1393949	-	243	WP_005443875.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
C1N50_RS06835	1394024..1394152	+	129	WP_103413773.1	DUF3265 domain-containing protein	-
C1N50_RS06840	1394594..1395568	+	975	WP_045491211.1	hypothetical protein	-
C1N50_RS06845	1395583..1395675	+	93	WP_012841671.1	DUF3265 domain-containing protein	-
C1N50_RS06850	1395754..1396476	+	723	WP_103412974.1	hypothetical protein	-
C1N50_RS06855	1396491..1396583	+	93	WP_199768353.1	DUF3265 domain-containing protein	-
C1N50_RS06860	1396615..1397073	+	459	WP_050914595.1	GNAT family N-acetyltransferase	-
C1N50_RS06865	1397219..1397776	+	558	WP_103412977.1	helix-turn-helix domain-containing protein	-
C1N50_RS06870	1397802..1397894	+	93	WP_004748931.1	DUF3265 domain-containing protein	-
C1N50_RS25750	1398690..1398779	+	90	Protein_1225	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1365505..1444722	79217
	-	flank	IS/Tn	-	-	1392161..1392937	776
	-	inside	Integron	-	-	1363760..1427815	64055

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11524.16 Da
• Isoelectric Point: 9.6267

>T93815 WP_045369102.1 NZ_CP026321:c1393699-1393400 [Vibrio campbellii]
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCHELYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T93815 NZ_CP026321:c1393699-1393400 [Vibrio campbellii]
ATGCAAAAGAATAAATACAAGCTAAGTAACTTAGCGCAATCCCACTTGCGCAAAGTCAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTATAAAGACACTTTGCTATCAGGGTTTCAGATGCTAGCTGATAATCCAGGTTTAGGAA
GAAGCTGTCACGAGCTATACCCAAATGGCTTTTATTTCCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATATTAGTCGTTGCTGTCTTAGGTCAATCACAGCTACCCCAGAATCATCTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9047.26 Da
• Isoelectric Point: 5.6926

>AT93815 WP_005443875.1 NZ_CP026321:c1393949-1393707 [Vibrio campbellii]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFINSL

Nucleotide

• Length: 243 bp

>AT93815 NZ_CP026321:c1393949-1393707 [Vibrio campbellii]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAGCCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACACTGTTGACGGCGAAAGCTTTATAAATTCGCTG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A812FW55