Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 2934264..2935030 Replicon chromosome
Accession NZ_CP026315
Organism Vibrio campbellii strain BoB-90

Toxin (Protein)


Gene name - Uniprot ID A0A3Q0L5V0
Locus tag C1N51_RS14165 Protein ID WP_011080392.1
Coordinates 2934264..2934761 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A3N3DV16
Locus tag C1N51_RS14170 Protein ID WP_013571703.1
Coordinates 2934758..2935030 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1N51_RS14110 2929646..2930614 - 969 WP_103410833.1 IS30-like element ISVa6 family transposase -
C1N51_RS29780 2930729..2930821 + 93 WP_199770609.1 DUF3265 domain-containing protein -
C1N51_RS14120 2931276..2931368 + 93 WP_193386937.1 DUF3265 domain-containing protein -
C1N51_RS14125 2931376..2931693 - 318 WP_038140554.1 CcdB family protein -
C1N51_RS14130 2931693..2931938 - 246 WP_038140558.1 type II toxin-antitoxin system CcdA family antitoxin -
C1N51_RS14135 2932013..2932105 + 93 WP_193255160.1 DUF3265 domain-containing protein -
C1N51_RS14140 2932142..2932453 + 312 WP_031850888.1 antibiotic biosynthesis monooxygenase -
C1N51_RS14145 2932986..2933078 + 93 WP_074534784.1 DUF3265 domain-containing protein -
C1N51_RS14150 2933105..2933512 + 408 WP_038892264.1 hypothetical protein -
C1N51_RS14155 2933541..2933630 + 90 WP_077201259.1 DUF3265 domain-containing protein -
C1N51_RS14160 2933659..2934123 + 465 WP_038892273.1 hypothetical protein -
C1N51_RS29610 2934114..2934230 + 117 WP_152442079.1 DUF3265 domain-containing protein -
C1N51_RS14165 2934264..2934761 - 498 WP_011080392.1 GNAT family N-acetyltransferase Toxin
C1N51_RS14170 2934758..2935030 - 273 WP_013571703.1 DUF1778 domain-containing protein Antitoxin
C1N51_RS29785 2935140..2935232 + 93 WP_086459316.1 DUF3265 domain-containing protein -
C1N51_RS14180 2935326..2935745 + 420 WP_077200592.1 hypothetical protein -
C1N51_RS14185 2935781..2935909 + 129 WP_199770565.1 DUF3265 domain-containing protein -
C1N51_RS14190 2935899..2937428 - 1530 WP_103410819.1 IS66 family transposase -
C1N51_RS14195 2937488..2937841 - 354 WP_103410057.1 IS66 family insertion sequence element accessory protein TnpB -
C1N51_RS14200 2937838..2938155 - 318 WP_103410056.1 IS66 family insertion sequence hypothetical protein -
C1N51_RS14205 2938413..2938847 + 435 Protein_2601 DUF2778 domain-containing protein -
C1N51_RS14210 2938894..2939690 + 797 WP_086028371.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2915399..2982177 66778
- flank IS/Tn - - 2929646..2930422 776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18486.13 Da        Isoelectric Point: 8.0487

>T93809 WP_011080392.1 NZ_CP026315:c2934761-2934264 [Vibrio campbellii]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFEDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T93809 NZ_CP026315:c2934761-2934264 [Vibrio campbellii]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAAAAAGACAACACCAGAACATTTGTTTTGGAAGATGATAACGACAACTCAC
ATGTCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAGTTACAAAAAAAACACCAA
TCATCCACCTCTGGTGGTCTGATTGCCCGCCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATTGACGCACTCAGAAAGCTATTAGCTGCAAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CGAAACACTTCTATGAACGCTATGGTTTTCAAGCATTTGAAGACGCTGAAAATAAACTCTTCATCACCATTGCTGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9747.28 Da        Isoelectric Point: 8.5960

>AT93809 WP_013571703.1 NZ_CP026315:c2935030-2934758 [Vibrio campbellii]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQNSKLKA
AADRYESKIQ

Download         Length: 273 bp

>AT93809 NZ_CP026315:c2935030-2934758 [Vibrio campbellii]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGTATGTCTAGCATCAACTCGTTCGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCAGATGCGATGTTGCTCATGGAAGCTTTAGACCGTCCTGCAACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5V0

Antitoxin

Source ID Structure
AlphaFold DB A0A3N3DV16

References