Detailed information of TA system TA093807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 838568..840185
• Replicon: plasmid unnamed
• Accession: NZ_CP026308
• Organism: Ralstonia solanacearum strain IBSBF 2571

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F6GA13
• Locus tag: C2124_RS19815
• Protein ID: WP_014619008.1
• Coordinates: 838568..839914 (-)
• Length: 449 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: C2124_RS19820
• Protein ID: WP_042549221.1
• Coordinates: 839919..840185 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2124_RS19790	833900..834046	+	147	WP_014619002.1	hypothetical protein	-
C2124_RS19795	834194..834820	-	627	WP_014619003.1	FMN-dependent NADH-azoreductase	-
C2124_RS19800	834959..835909	+	951	WP_039552434.1	LysR family transcriptional regulator	-
C2124_RS19805	836002..837573	+	1572	WP_014619006.1	MFS transporter	-
C2124_RS19810	837577..838473	-	897	WP_014619007.1	DUF2236 domain-containing protein	-
C2124_RS19815	838568..839914	-	1347	WP_014619008.1	type II toxin-antitoxin system HipA family toxin	Toxin
C2124_RS19820	839919..840185	-	267	WP_042549221.1	helix-turn-helix domain-containing protein	Antitoxin
C2124_RS19825	840444..841295	+	852	WP_124994750.1	hypothetical protein	-
C2124_RS19830	841311..841745	-	435	WP_042549879.1	PGDYG domain-containing protein	-
C2124_RS19835	842002..842385	+	384	WP_174265706.1	VOC family protein	-
C2124_RS19840	842424..843542	-	1119	WP_014619013.1	dienelactone hydrolase	-
C2124_RS19845	843545..844381	-	837	WP_014619014.1	AraC family transcriptional regulator	-
C2124_RS19850	844484..844960	-	477	WP_003265832.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	cheY / cyaB / motA / cheB / cheY / adeG / acrB / fliI / fliM / flgG / flgC	1..1949116	1949116

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (159-413)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-67)

Sequences

Toxin

Protein

• Length: 449 a.a.
• Molecular weight: 49543.83 Da
• Isoelectric Point: 7.8550

>T93807 WP_014619008.1 NZ_CP026308:c839914-838568 [Ralstonia solanacearum]
MGRRSHTRALGLWMNGTHVGRWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPHKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPPATGDIDAEPLTEAQIAQTLRETVAPPPLGGMPEDDSHFRIS
IAGAQEKTAFLQIDGHWYRPRGATPTSHIFKLPMGLVGNMKLDLSDSVENEWLCALVLRAYGLPVAHCRPLVFEDQKVLA
VERFDRMWWDRGGKRLLRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSAHREADRLTLFRSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNAHWKMQDIQRRHWLGLGQRYGIVTSDGAD
AASIVDNLVARTPEVARTVRALLPEGFPQPLADRILQGLRHAADKLAG

Nucleotide

• Length: 1347 bp

>T93807 NZ_CP026308:c839914-838568 [Ralstonia solanacearum]
ATGGGGCGCCGGTCGCATACGCGGGCCCTCGGGCTCTGGATGAATGGCACCCATGTCGGCCGCTGGGAGCTGCACCCGCA
CCAGGGCGACGTGCTGAAGTACGCGGCATCCTGGGTGGCCGCGCCCGAGGGTCGGCCCCTGTCGCTGTCCCTGCCGTTCA
CGCCGGACAACGCGCCCCACAAGGGCCCGGCGGTCCGGGCGTATTTCGAGAACCTCCTGCCGGACAGCCGCGACATCCGC
GAGCGCATCGCGCGCCGTTTCCAGGCCGGGACAACCGAGGCGTTCGACCTGCTGGAGCAGATCGGCCGCGACTGCATCGG
CGCCCTGCAAGTGCTGCCGGCCGACATGGCCCCACCGGCCACGGGCGACATCGACGCGGAACCGCTGACCGAGGCGCAGA
TCGCGCAGACGCTGCGGGAGACCGTCGCCCCGCCCCCCTTGGGCGGCATGCCGGAAGACGATAGCCATTTCCGCATCTCG
ATCGCCGGCGCGCAGGAAAAGACGGCCTTCCTCCAGATCGACGGACACTGGTACCGCCCCCGGGGCGCGACGCCAACCAG
CCACATCTTCAAGCTGCCGATGGGGCTGGTCGGCAACATGAAGCTGGACCTGAGCGATTCGGTGGAAAACGAATGGCTGT
GCGCCCTGGTGCTGCGGGCGTATGGCCTGCCCGTCGCGCACTGCCGGCCGCTGGTGTTCGAAGACCAGAAGGTGCTCGCC
GTGGAGCGGTTCGACCGCATGTGGTGGGACCGCGGCGGCAAACGGCTCCTCCGCCTGCCGCAGGAAGACATGTGCCAGGC
CACGGCGACGCCCCCGCACCTGAAGTACGAGGCCGACGGCGGCCCCGGCATCGACCGCATCATGGGCCTGCTCGACGGCT
CCGCGCACCGGGAGGCCGACCGCCTGACGCTGTTCCGCAGCCAGGTGCTGTTCTGGATGCTGTGTGCGCCCGATGGCCAC
GCGAAGAACTTCAGCCTCGCGCTACGTCCCGGCGGCGCCTACGCGCTCACGCCGCTGTACGACGTGATGTCGGCCTACCC
GCTGCTGGGCGAGGGGCCGGGCAAGCTGTCGCCGCACCGGATCCGGCTGGCGATGGCCGTCCGCTCGAAGAATGCGCACT
GGAAAATGCAGGACATCCAGCGTCGCCACTGGCTGGGCCTGGGCCAACGCTACGGCATCGTCACGTCCGATGGCGCGGAT
GCCGCCTCCATCGTGGACAACCTGGTGGCCCGGACGCCCGAGGTGGCCCGTACCGTGCGCGCGCTGCTGCCGGAAGGCTT
CCCGCAGCCGCTGGCCGACCGCATTCTGCAGGGGCTGCGGCACGCTGCGGACAAACTCGCGGGATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9636.14 Da
• Isoelectric Point: 10.9487

>AT93807 WP_042549221.1 NZ_CP026308:c840185-839919 [Ralstonia solanacearum]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGVRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDAAGEPGR
PASDQPQW

Nucleotide

• Length: 267 bp

>AT93807 NZ_CP026308:c840185-839919 [Ralstonia solanacearum]
ATGAACGAGTTCATCGTACGCACCCCCGAGCAGTTGCCGGCGATCCTCAAGGGCTTCCGTAAACAGGCCGGGCTGAGCCA
GGCCGAACTGGCCGCCCGGATGGGCGTGCGCCAGCAAACCCTCTCAGCGCTGGAGCGCAACGCAGAAAACGTGAGCGCCG
GGCGGCTGATGCGCCTGCTGTCGGTGCTGGGCGTGGAGCTGGTGCTGCGCAAACCCGACGCCGCCGGCGAGCCCGGCCGC
CCGGCGTCCGACCAGCCGCAGTGGTGA

Structures

Toxin

• AlphaFold DB: F6GA13