Detailed information of TA system TA093803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 459106..459739
• Replicon: chromosome
• Accession: NZ_CP026307
• Organism: Ralstonia solanacearum strain IBSBF 2571

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: F6FXL1
• Locus tag: C2124_RS02095
• Protein ID: WP_014615899.1
• Coordinates: 459326..459739 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: F6FXL0
• Locus tag: C2124_RS02090
• Protein ID: WP_003263271.1
• Coordinates: 459106..459339 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2124_RS02075	454680..455969	-	1290	WP_003263268.1	MFS transporter	-
C2124_RS02080	455977..457245	-	1269	WP_124994693.1	AGE family epimerase/isomerase	-
C2124_RS02085	457441..459048	+	1608	WP_039567295.1	glucan biosynthesis protein	-
C2124_RS02090	459106..459339	+	234	WP_003263271.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
C2124_RS02095	459326..459739	+	414	WP_014615899.1	PIN domain-containing protein	Toxin
C2124_RS02100	459714..460340	-	627	WP_014615900.1	DUF1415 family protein	-
C2124_RS02105	460551..460925	+	375	WP_014615901.1	hypothetical protein	-
C2124_RS02110	461000..462496	-	1497	WP_014615902.1	glycerol kinase GlpK	-
C2124_RS02115	462668..464404	-	1737	WP_174265000.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-116)

Antitoxin

• SpoVT-AbrB domain (5-40)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14919.23 Da
• Isoelectric Point: 5.9701

>T93803 WP_014615899.1 NZ_CP026307:459326-459739 [Ralstonia solanacearum]
MPAAEAFFDSNIVLYLLSADAAKADAAEALLMAGGVVSVQVLNETTHVMRRKLAMPWHAIEAVQEAVRAQCRVEPLTVET
HDLGRHLAQRYGLSVYDALIVAAASLAGCRVLYSEDMQHGLVIEQRLRVVNPFFASA

Nucleotide

• Length: 414 bp

>T93803 NZ_CP026307:459326-459739 [Ralstonia solanacearum]
ATGCCCGCGGCTGAGGCGTTTTTCGACAGCAACATCGTGCTGTACCTGCTGTCGGCCGATGCCGCCAAGGCCGATGCGGC
GGAAGCGCTACTGATGGCCGGCGGCGTCGTCAGCGTGCAGGTGCTCAACGAAACGACGCACGTGATGCGCCGCAAGCTCG
CCATGCCGTGGCACGCGATCGAAGCGGTGCAGGAAGCCGTACGCGCGCAATGCCGGGTCGAGCCGCTGACGGTCGAAACC
CATGATCTCGGGCGGCATCTTGCGCAGCGCTATGGATTGTCGGTCTATGACGCGCTGATCGTCGCCGCAGCGTCGCTGGC
CGGTTGCCGCGTCCTGTATTCCGAGGACATGCAGCACGGCCTGGTGATCGAGCAGCGTCTGCGCGTCGTCAATCCTTTTT
TCGCGTCGGCGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8664.82 Da
• Isoelectric Point: 8.7288

>AT93803 WP_003263271.1 NZ_CP026307:459106-459339 [Ralstonia solanacearum]
MQVSKWGNSLAIRLPAAVVEALGLHEGDDVEVVVAGERSFGVRRKRSARELFERLHQYRGKLPADFIFERDDANARG

Nucleotide

• Length: 234 bp

>AT93803 NZ_CP026307:459106-459339 [Ralstonia solanacearum]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCCATCCGGCTGCCCGCAGCCGTTGTGGAGGCGCTTGGACTGCACGAAGG
CGACGACGTCGAGGTGGTGGTGGCGGGCGAACGCTCGTTTGGTGTGCGCCGCAAGCGTTCCGCGCGTGAGTTGTTTGAGC
GGCTCCACCAATACCGCGGCAAGCTGCCCGCCGACTTCATCTTCGAGCGCGACGACGCCAATGCCCGCGGCTGA

Structures

Toxin

• AlphaFold DB: F6FXL1

Antitoxin

• AlphaFold DB: F6FXL0