Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 192107..192632 Replicon plasmid pKOR-ab4d
Accession NZ_CP026276
Organism Klebsiella oxytoca strain KONIH5

Toxin (Protein)


Gene name ccdB Uniprot ID J5VBT8
Locus tag C2U46_RS31410 Protein ID WP_004197633.1
Coordinates 192107..192412 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1D8K3R4
Locus tag C2U46_RS31415 Protein ID WP_006788213.1
Coordinates 192414..192632 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U46_RS31380 187717..188097 - 381 WP_032694621.1 hypothetical protein -
C2U46_RS31385 188304..188588 + 285 WP_000537152.1 IS3 family transposase -
C2U46_RS31390 188585..189439 + 855 WP_077253370.1 IS3 family transposase -
C2U46_RS31395 189538..189855 + 318 WP_103449271.1 hypothetical protein -
C2U46_RS31400 189936..190718 - 783 WP_032694612.1 site-specific integrase -
C2U46_RS31405 190916..191920 - 1005 WP_032694611.1 hypothetical protein -
C2U46_RS31410 192107..192412 - 306 WP_004197633.1 type II toxin-antitoxin system toxin CcdB Toxin
C2U46_RS31415 192414..192632 - 219 WP_006788213.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
C2U46_RS32680 192802..193263 - 462 Protein_229 hypothetical protein -
C2U46_RS31425 193220..193450 + 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
C2U46_RS31430 193447..193863 + 417 WP_016236302.1 type II toxin-antitoxin system VapC family toxin -
C2U46_RS31435 193937..195499 + 1563 WP_004206609.1 AAA family ATPase -
C2U46_RS31440 195484..196506 + 1023 WP_000361404.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..282476 282476


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11585.27 Da        Isoelectric Point: 6.4661

>T93800 WP_004197633.1 NZ_CP026276:c192412-192107 [Klebsiella oxytoca]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T93800 NZ_CP026276:c192412-192107 [Klebsiella oxytoca]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTCGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCCGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCAATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8362.31 Da        Isoelectric Point: 4.7405

>AT93800 WP_006788213.1 NZ_CP026276:c192632-192414 [Klebsiella oxytoca]
MKQRITVTIDSDSYQLLKSADVNISGLVNRAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT93800 NZ_CP026276:c192632-192414 [Klebsiella oxytoca]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCGGACGTCAATATCTCCGGCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCCGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCTGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MCG5

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8K3R4

References