Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 3467926..3468745 Replicon chromosome
Accession NZ_CP026275
Organism Klebsiella oxytoca strain KONIH5

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag C2U46_RS16890 Protein ID WP_004110819.1
Coordinates 3467926..3468183 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A2J5QA69
Locus tag C2U46_RS16895 Protein ID WP_032693191.1
Coordinates 3468194..3468745 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U46_RS16875 3463602..3464378 - 777 WP_004847986.1 Uxu operon transcriptional regulator -
C2U46_RS16880 3464517..3465992 - 1476 WP_014228053.1 fructuronate reductase -
C2U46_RS16885 3466066..3467250 - 1185 WP_014228054.1 mannonate dehydratase -
C2U46_RS16890 3467926..3468183 + 258 WP_004110819.1 YjhX family toxin Toxin
C2U46_RS16895 3468194..3468745 + 552 WP_032693191.1 N-acetyltransferase Antitoxin
C2U46_RS16900 3468763..3470391 + 1629 WP_032693192.1 SAM-dependent methyltransferase -
C2U46_RS32540 3470425..3470583 + 159 Protein_3182 hypothetical protein -
C2U46_RS16905 3470580..3470995 + 416 Protein_3183 type II toxin-antitoxin system VapC family toxin -
C2U46_RS16910 3471264..3471737 - 474 WP_032693194.1 hypothetical protein -
C2U46_RS16915 3472048..3472821 - 774 WP_088168442.1 Zygote formation protein zyg1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T93787 WP_004110819.1 NZ_CP026275:3467926-3468183 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T93787 NZ_CP026275:3467926-3468183 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20154.00 Da        Isoelectric Point: 6.4903

>AT93787 WP_032693191.1 NZ_CP026275:3468194-3468745 [Klebsiella oxytoca]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQMVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQRLSS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp

>AT93787 NZ_CP026275:3468194-3468745 [Klebsiella oxytoca]
ATGACAAACCATAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGTGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGATGGTATTTGTTCTGGGCCACGCCGCTTACTACCCCAGGCACGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCGGAGGCGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCT
CAGCCTCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A2J5QA69

References