Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1375294..1376072 Replicon chromosome
Accession NZ_CP026275
Organism Klebsiella oxytoca strain KONIH5

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1D8JZH2
Locus tag C2U46_RS06670 Protein ID WP_032692863.1
Coordinates 1375294..1375782 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A1D8JZH7
Locus tag C2U46_RS06675 Protein ID WP_032692864.1
Coordinates 1375779..1376072 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U46_RS06655 1370817..1372727 + 1911 WP_032692860.1 hypothetical protein -
C2U46_RS06660 1372724..1374424 + 1701 WP_032692861.1 hypothetical protein -
C2U46_RS06665 1374531..1375229 - 699 WP_032692862.1 hypothetical protein -
C2U46_RS06670 1375294..1375782 - 489 WP_032692863.1 GNAT family N-acetyltransferase Toxin
C2U46_RS06675 1375779..1376072 - 294 WP_032692864.1 DUF1778 domain-containing protein Antitoxin
C2U46_RS06680 1376451..1377839 - 1389 WP_032692865.1 DASS family sodium-coupled anion symporter -
C2U46_RS32525 1378035..1378211 - 177 WP_177341169.1 hypothetical protein -
C2U46_RS06685 1378385..1379755 + 1371 WP_025105933.1 cystathionine beta-synthase -
C2U46_RS06690 1379766..1380911 + 1146 WP_004854188.1 PLP-dependent aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17694.67 Da        Isoelectric Point: 8.1567

>T93783 WP_032692863.1 NZ_CP026275:c1375782-1375294 [Klebsiella oxytoca]
MISTPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCHDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSNEAREFYLRVGFEPSLIDPMMLMVTLGDLVE
SI

Download         Length: 489 bp

>T93783 NZ_CP026275:c1375782-1375294 [Klebsiella oxytoca]
ATGATCTCCACACCAGAGCCGCTTCATGCCGGGCACATTCTAACCCCGTTCTGCTGCGGCGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAGAACCAGCTTTCTGGCGCGTCCCGTACGTTTGTCTGCTGCCACGATGCTAAGGTGATGG
CTTACTACTCGCTGGCGTCCAGCGCGGTAACGACAAACACCGCCCCCGGCCGCTTTCGTCGCAATATGCCCGATCCGATC
CCGGTTGTAGTGCTGGGACGTCTGGCGGTGGATCGGTCGCTACATGGACAAGGCGTTGGGCGGGCGCTGGTGAGGGATGC
CGGACTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGCTGGTTCACGCTCTGTCGAATGAAGCGCGGG
AGTTTTACCTGCGCGTGGGGTTCGAGCCATCGCTGATAGATCCGATGATGCTCATGGTGACTTTGGGGGATTTGGTGGAG
AGTATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10930.56 Da        Isoelectric Point: 9.9171

>AT93783 WP_032692864.1 NZ_CP026275:c1376072-1375779 [Klebsiella oxytoca]
MPAANSMAMKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT93783 NZ_CP026275:c1376072-1375779 [Klebsiella oxytoca]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACTCTGAACCTGCGCATCAGGCCCGCTGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGAAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGCGCTGCTGCCGAGGAAGCGTTGA
TCGAGCAGCGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTTGCCCGTCTGGATCAGGCTCCTGCGCCCAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8JZH2

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8JZH7

References