Detailed information of TA system TA093775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 5033167..5033986
• Replicon: chromosome
• Accession: NZ_CP026269
• Organism: Klebsiella oxytoca strain KONIH4

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: C2U44_RS24975
• Protein ID: WP_004110819.1
• Coordinates: 5033729..5033986 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: C2U44_RS24970
• Protein ID: WP_042944337.1
• Coordinates: 5033167..5033718 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U44_RS24950	5029091..5029864	+	774	WP_103433587.1	Zygote formation protein zyg1	-
C2U44_RS24955	5030175..5030648	+	474	WP_032693194.1	hypothetical protein	-
C2U44_RS24960	5030917..5031332	-	416	Protein_4761	type II toxin-antitoxin system VapC family toxin	-
C2U44_RS35580	5031329..5031487	-	159	Protein_4762	hypothetical protein	-
C2U44_RS24965	5031521..5033149	-	1629	WP_014837490.1	SAM-dependent methyltransferase	-
C2U44_RS24970	5033167..5033718	-	552	WP_042944337.1	N-acetyltransferase	Antitoxin
C2U44_RS24975	5033729..5033986	-	258	WP_004110819.1	YjhX family toxin	Toxin
C2U44_RS24980	5034662..5035846	+	1185	WP_014228054.1	mannonate dehydratase	-
C2U44_RS24985	5035920..5037395	+	1476	WP_014228053.1	fructuronate reductase	-
C2U44_RS24990	5037534..5038310	+	777	WP_004847986.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (22-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T93775 WP_004110819.1 NZ_CP026269:c5033986-5033729 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T93775 NZ_CP026269:c5033986-5033729 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19872.62 Da
• Isoelectric Point: 6.3261

>AT93775 WP_042944337.1 NZ_CP026269:c5033718-5033167 [Klebsiella oxytoca]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAACYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCAWALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT93775 NZ_CP026269:c5033718-5033167 [Klebsiella oxytoca]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTGCTACCCCAGGCACGGGTTTGAGCCAGGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCTGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2