Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4962892..4963674 Replicon chromosome
Accession NZ_CP026269
Organism Klebsiella oxytoca strain KONIH4

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag C2U44_RS24615 Protein ID WP_042944403.1
Coordinates 4962892..4963266 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag C2U44_RS24620 Protein ID WP_042944401.1
Coordinates 4963318..4963674 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U44_RS24580 4958116..4959219 + 1104 WP_004848066.1 glutamate 5-kinase -
C2U44_RS24585 4959230..4960483 + 1254 WP_014228088.1 glutamate-5-semialdehyde dehydrogenase -
C2U44_RS24595 4960773..4961619 - 847 Protein_4688 DUF4942 domain-containing protein -
C2U44_RS24600 4961701..4961904 - 204 WP_023568001.1 DUF957 domain-containing protein -
C2U44_RS24605 4961931..4962422 - 492 WP_042944408.1 hypothetical protein -
C2U44_RS24610 4962419..4962796 - 378 WP_042944406.1 TA system toxin CbtA family protein -
C2U44_RS24615 4962892..4963266 - 375 WP_042944403.1 TA system toxin CbtA family protein Toxin
C2U44_RS24620 4963318..4963674 - 357 WP_042944401.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C2U44_RS24625 4963726..4964370 - 645 WP_042944399.1 hypothetical protein -
C2U44_RS24630 4964386..4964607 - 222 WP_042944397.1 DUF987 domain-containing protein -
C2U44_RS24635 4964622..4965101 - 480 WP_042944395.1 DNA repair protein RadC -
C2U44_RS24640 4965113..4965583 - 471 WP_023567995.1 antirestriction protein -
C2U44_RS24645 4965664..4966485 - 822 WP_042944391.1 DUF945 domain-containing protein -
C2U44_RS24650 4966596..4966829 - 234 WP_042944390.1 DUF905 domain-containing protein -
C2U44_RS24655 4966917..4967861 - 945 WP_077255291.1 hypothetical protein -
C2U44_RS24660 4967914..4968129 - 216 WP_042944388.1 hypothetical protein -
C2U44_RS35555 4968141..4968290 - 150 WP_001458941.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(18-110)

Antitoxin

Antitoxin CbeA

(15-113)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13571.26 Da        Isoelectric Point: 4.5407

>T93774 WP_042944403.1 NZ_CP026269:c4963266-4962892 [Klebsiella oxytoca]
MRIYPVSAKRAAEIERLSPVSPVAVWQRLLTYLLDRHYGLTLNDTQFGDDGTIQECIDVGDPLLDALNEVVEDDELERTD
NRGKSLLFRSSLLTPADIRNAQKAVGLAGNSASLIISGQSSARS

Download         Length: 375 bp

>T93774 NZ_CP026269:c4963266-4962892 [Klebsiella oxytoca]
ATGAGAATTTATCCTGTATCCGCAAAACGGGCCGCTGAGATTGAGCGGTTATCGCCTGTGTCACCGGTTGCCGTCTGGCA
GCGCCTCCTGACGTACCTGCTGGACCGTCACTACGGTCTGACGCTTAACGATACTCAGTTTGGCGATGACGGCACCATTC
AGGAATGCATTGACGTCGGTGATCCCCTGCTTGACGCCCTGAACGAAGTGGTTGAAGACGACGAGCTGGAGCGTACTGAT
AACCGGGGAAAATCACTTCTGTTCAGATCGTCGCTGCTCACACCCGCAGATATCCGGAACGCCCAGAAAGCCGTGGGTCT
GGCAGGCAACAGCGCCTCCCTCATTATCAGCGGTCAGTCGTCAGCCAGAAGCTAA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13079.82 Da        Isoelectric Point: 6.3170

>AT93774 WP_042944401.1 NZ_CP026269:c4963674-4963318 [Klebsiella oxytoca]
MPDIPATNDNMDAPRWGLQRNITPCFGARLVQEGNRLHYLADRASINGTFSDADLRHLDQSFPLLLKQLELMLVSGELNP
RHQHSVTLYAKGLTCEADSLASHGYVYIAIYPTPATTA

Download         Length: 357 bp

>AT93774 NZ_CP026269:c4963674-4963318 [Klebsiella oxytoca]
ATGCCAGATATCCCTGCCACAAATGACAATATGGACGCGCCGCGCTGGGGTCTTCAGCGCAATATCACGCCCTGTTTTGG
CGCTCGCCTGGTGCAGGAGGGCAACCGGCTGCATTACCTGGCTGACCGCGCCAGTATCAACGGAACCTTCAGCGATGCGG
ATTTACGCCATCTCGACCAGTCGTTTCCGCTGCTGTTGAAACAACTGGAACTGATGCTGGTTTCCGGTGAACTCAATCCC
CGTCATCAACACAGCGTTACGCTTTACGCAAAAGGGCTGACCTGCGAGGCCGACAGCCTCGCTTCGCACGGGTACGTCTA
TATCGCAATTTATCCGACACCAGCCACAACCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References