Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4673558..4674329 Replicon chromosome
Accession NZ_CP026269
Organism Klebsiella oxytoca strain KONIH4

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag C2U44_RS23145 Protein ID WP_044349763.1
Coordinates 4673558..4673947 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag C2U44_RS23150 Protein ID WP_181015783.1
Coordinates 4674003..4674329 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U44_RS23125 4669166..4671142 + 1977 WP_042944482.1 glycoside hydrolase family 28 protein -
C2U44_RS23130 4671365..4671979 - 615 WP_042944480.1 FMN-binding negative transcriptional regulator -
C2U44_RS35545 4672313..4672453 + 141 Protein_4406 integrase -
C2U44_RS23140 4672626..4673471 - 846 WP_044349761.1 DUF4942 domain-containing protein -
C2U44_RS23145 4673558..4673947 - 390 WP_044349763.1 TA system toxin CbtA family protein Toxin
C2U44_RS23150 4674003..4674329 - 327 WP_181015783.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C2U44_RS23155 4674387..4674608 - 222 WP_044349767.1 DUF987 domain-containing protein -
C2U44_RS23160 4674622..4675101 - 480 WP_044349769.1 DNA repair protein RadC -
C2U44_RS23165 4675113..4675556 - 444 WP_044349771.1 antirestriction protein -
C2U44_RS23170 4675625..4675873 - 249 WP_044349773.1 DUF905 domain-containing protein -
C2U44_RS23175 4675879..4676703 - 825 WP_044349775.1 DUF945 domain-containing protein -
C2U44_RS23180 4677238..4677870 + 633 WP_103433582.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14262.19 Da        Isoelectric Point: 9.5909

>T93772 WP_044349763.1 NZ_CP026269:c4673947-4673558 [Klebsiella oxytoca]
MQTKSSPLARAASSRPSPTGVWQALLTSLLEHHYGLTLSDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGF
SILTQSPFITPIDILRARKATGLMNRDTYKEVTATTRGQHTQVSAPGKR

Download         Length: 390 bp

>T93772 NZ_CP026269:c4673947-4673558 [Klebsiella oxytoca]
ATGCAAACCAAATCATCCCCCCTCGCGCGGGCGGCATCGTCACGTCCGTCTCCCACGGGTGTCTGGCAGGCTCTGCTGAC
CAGCCTGCTGGAACACCACTATGGCCTCACGCTTAGCGATACGCCGTTCAGTGATGAACAGGTCATTCAGCAACATATTG
ATGCCGGTATCTCGCTGGTTGATGCCCTGAATTTTATCGTTGAGAAGTATGAACTGGTCCGCACTGACCGCCCAGGCTTC
AGCATCCTGACGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGGAAAGCAACGGGGCTGATGAACCGTGA
CACGTATAAAGAGGTGACGGCTACTACCAGAGGGCAACATACGCAGGTCAGCGCTCCAGGCAAGCGATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12053.74 Da        Isoelectric Point: 6.3101

>AT93772 WP_181015783.1 NZ_CP026269:c4674329-4674003 [Klebsiella oxytoca]
ISEPWWGLRCSASPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQAFPVLMKQLELMLTSGELNPRHQHCVTLYA
KGLTCEADTLGSHGYVYIAIYPTPVATA

Download         Length: 327 bp

>AT93772 NZ_CP026269:c4674329-4674003 [Klebsiella oxytoca]
ATCAGCGAACCCTGGTGGGGACTCAGATGCAGTGCCTCCCCGTGTTTTGGTGCCCGTCTGGTCCAGGAGGGGAACCGCCT
GCATTACCTGGCTGACCGTGCGAACTTTGATGGTCAGTTCTGCGATGCGGATTTGCGCCATCTTGACCAGGCTTTCCCGG
TATTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAATCCCCGTCATCAGCACTGCGTCACACTGTATGCA
AAAGGCCTGACCTGCGAGGCCGATACGCTCGGTTCGCACGGTTATGTTTATATCGCGATTTATCCCACTCCTGTCGCCAC
GGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References