Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1382666..1383219 Replicon chromosome
Accession NZ_CP026269
Organism Klebsiella oxytoca strain KONIH4

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag C2U44_RS06950 Protein ID WP_016157234.1
Coordinates 1382905..1383219 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag C2U44_RS06945 Protein ID WP_016157235.1
Coordinates 1382666..1382902 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U44_RS06930 1379216..1379722 - 507 WP_032931759.1 hypothetical protein -
C2U44_RS06935 1379719..1380927 - 1209 WP_042945865.1 hypothetical protein -
C2U44_RS06940 1381399..1382343 + 945 WP_042945864.1 DUF1738 domain-containing protein -
C2U44_RS06945 1382666..1382902 + 237 WP_016157235.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
C2U44_RS06950 1382905..1383219 + 315 WP_016157234.1 CcdB family protein Toxin
C2U44_RS06955 1383216..1383968 - 753 WP_016157233.1 hypothetical protein -
C2U44_RS06960 1383977..1385713 - 1737 WP_042945862.1 type IV secretory system conjugative DNA transfer family protein -
C2U44_RS06975 1386490..1386795 - 306 WP_016157231.1 hypothetical protein -
C2U44_RS35095 1386842..1387072 - 231 Protein_1315 kikA from plasmid origin -
C2U44_RS06985 1387222..1388202 - 981 WP_016947617.1 IS5-like element ISKpn26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1312281..1424231 111950
- flank IS/Tn - - 1387222..1388202 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11415.29 Da        Isoelectric Point: 8.9025

>T93762 WP_016157234.1 NZ_CP026269:1382905-1383219 [Klebsiella oxytoca]
MQFTVYGNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPAGRYPAGRRPERLVPVVRLTDGQEYAVMTHELASVPVRALG
AVFCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

>T93762 NZ_CP026269:1382905-1383219 [Klebsiella oxytoca]
ATGCAGTTCACCGTATACGGAAACACCGGTAAAAGCGCCGTTTACCCTCTGCTGCTTGATGTCACGAGCGATATTATCGG
ACAACTGAACCGCCGGATCGTGATCCCGCTGCTGCCTGCTGGCAGGTATCCGGCAGGACGCCGCCCGGAGCGTCTTGTCC
CTGTCGTCAGACTGACAGACGGTCAGGAATACGCGGTCATGACCCACGAACTGGCGAGTGTCCCTGTCCGGGCGCTGGGA
GCGGTTTTCTGCGATGCGTCTCAATACCGCACTCAGGTGAAGGCCGCCATCGATTTCCTCATTGACGGCATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9044.08 Da        Isoelectric Point: 6.2206

>AT93762 WP_016157235.1 NZ_CP026269:1382666-1382902 [Klebsiella oxytoca]
MTAKQRSTQSVTMTVERALLIRAREAGINLSATLTTALDAELRHYEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT93762 NZ_CP026269:1382666-1382902 [Klebsiella oxytoca]
ATGACCGCGAAACAACGCAGCACGCAGAGTGTGACCATGACGGTAGAGCGCGCCTTACTGATCCGGGCACGTGAGGCAGG
CATTAACCTCAGTGCGACCCTGACAACCGCCCTGGATGCGGAGCTTCGCCACTATGAAGCGAAAAAATGGCAGGAAGAGA
ACCGGGAGGCCATCGACGCATTAAATCGTTTCCATGATGAGCATGGCTGTTTCAGTGATGAATACCGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References