Detailed information of TA system TA093761

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 912029..912686
• Replicon: chromosome
• Accession: NZ_CP026269
• Organism: Klebsiella oxytoca strain KONIH4

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: C2U44_RS04615
• Protein ID: WP_042946033.1
• Coordinates: 912276..912686 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: H3N295
• Locus tag: C2U44_RS04610
• Protein ID: WP_004124953.1
• Coordinates: 912029..912295 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U44_RS04595	907263..907688	-	426	WP_032720093.1	PTS sugar transporter subunit IIA	-
C2U44_RS04600	907809..910607	-	2799	WP_014226794.1	transcriptional regulator DagR	-
C2U44_RS04605	910801..911784	-	984	WP_032720095.1	tRNA-modifying protein YgfZ	-
C2U44_RS04610	912029..912295	+	267	WP_004124953.1	FAD assembly factor SdhE	Antitoxin
C2U44_RS04615	912276..912686	+	411	WP_042946033.1	protein YgfX	Toxin
C2U44_RS04620	912695..913216	-	522	WP_014226792.1	flavodoxin FldB	-
C2U44_RS04625	913338..914234	+	897	WP_004105555.1	site-specific tyrosine recombinase XerD	-
C2U44_RS04630	914257..914970	+	714	WP_004854054.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
C2U44_RS04635	914976..916709	+	1734	WP_038423602.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16137.00 Da
• Isoelectric Point: 10.9455

>T93761 WP_042946033.1 NZ_CP026269:912276-912686 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVATLVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Nucleotide

• Length: 411 bp

>T93761 NZ_CP026269:912276-912686 [Klebsiella oxytoca]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGAC
GCTTGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10411.88 Da
• Isoelectric Point: 5.1296

>AT93761 WP_004124953.1 NZ_CP026269:912029-912295 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT93761 NZ_CP026269:912029-912295 [Klebsiella oxytoca]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGATAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3H3L9