93760

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 97840..98387 Replicon chromosome
Accession NZ_CP026269
Organism Klebsiella oxytoca strain KONIH4

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0H3H5T3
Locus tag C2U44_RS00495 Protein ID WP_014227299.1
Coordinates 97840..98148 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0H3H0P7
Locus tag C2U44_RS00500 Protein ID WP_014227298.1
Coordinates 98151..98387 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U44_RS00465 93487..93798 - 312 WP_014227304.1 PTS sugar transporter subunit IIB -
C2U44_RS00470 94093..95034 + 942 WP_014227303.1 LacI family transcriptional regulator -
C2U44_RS00475 95058..95351 - 294 WP_014227302.1 hypothetical protein -
C2U44_RS00480 95561..96526 + 966 WP_038423881.1 Rpn family recombination-promoting nuclease/putative transposase -
C2U44_RS00485 96526..96783 + 258 WP_042946138.1 hypothetical protein -
C2U44_RS00490 96787..97689 - 903 WP_014227300.1 EamA family transporter -
C2U44_RS00495 97840..98148 - 309 WP_014227299.1 CcdB family protein Toxin
C2U44_RS00500 98151..98387 - 237 WP_014227298.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
C2U44_RS00505 98493..99926 - 1434 WP_032718833.1 PTS N-acetylmuramic acid transporter subunit IIBC -
C2U44_RS00510 99951..100853 - 903 WP_009654080.1 N-acetylmuramic acid 6-phosphate etherase -
C2U44_RS00515 101014..102180 - 1167 WP_042946137.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11725.57 Da        Isoelectric Point: 7.2729

>T93760 WP_014227299.1 NZ_CP026269:c98148-97840 [Klebsiella oxytoca]
MQYYVYKNTGRIAAYPYLLDVQSDIIGKRNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

>T93760 NZ_CP026269:c98148-97840 [Klebsiella oxytoca]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CAAGCGCAATACTCGGGTCGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGTATCCCACATCGTGTTCTGGGTGAAGAA
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8783.92 Da        Isoelectric Point: 5.7928

>AT93760 WP_014227298.1 NZ_CP026269:c98387-98151 [Klebsiella oxytoca]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENAQAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp

>AT93760 NZ_CP026269:c98387-98151 [Klebsiella oxytoca]
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCAGGCCTGGTCAAACAGGCTCGTGAGGTCGG
CATCAATCTGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCAGGCAATCGACTACCTCAATAATTTAACTGAGGAAAATGGACTTCTCTCTGATGAATACAGGACGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H5T3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H0P7

References