93758

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 23564..24095 Replicon plasmid pBAM1
Accession NZ_CP026268
Organism Aminobacter sp. MSH1

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag CO731_RS28420 Protein ID WP_011114071.1
Coordinates 23814..24095 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag CO731_RS28415 Protein ID WP_011114070.1
Coordinates 23564..23827 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO731_RS28370 18674..19438 - 765 WP_013397098.1 ParA family protein -
CO731_RS28375 19435..19743 - 309 WP_011255197.1 transcriptional regulator -
CO731_RS28380 19987..20274 - 288 Protein_18 DUF2761 domain-containing protein -
CO731_RS28385 20276..20602 - 327 WP_012478184.1 hypothetical protein -
CO731_RS28390 20812..21048 - 237 WP_011255200.1 stable inheritance protein KleA -
CO731_RS28395 21206..21463 - 258 WP_012478185.1 hypothetical protein -
CO731_RS28400 21480..22688 - 1209 WP_012478186.1 hypothetical protein -
CO731_RS28405 22700..22963 - 264 WP_011296181.1 hypothetical protein -
CO731_RS28410 22963..23391 - 429 WP_011114069.1 antirestriction protein -
CO731_RS28415 23564..23827 + 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CO731_RS28420 23814..24095 + 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
CO731_RS28435 25481..26704 - 1224 WP_011013257.1 replication initiator protein A -
CO731_RS28440 26753..27091 - 339 WP_011013259.1 single-stranded DNA-binding protein -
CO731_RS28445 27201..27560 + 360 WP_011013260.1 transcriptional regulator -
CO731_RS28450 27875..28840 + 966 WP_011013261.1 P-type conjugative transfer ATPase TrbB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..40564 40564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T93758 WP_011114071.1 NZ_CP026268:23814-24095 [Aminobacter sp. MSH1]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T93758 NZ_CP026268:23814-24095 [Aminobacter sp. MSH1]
ATGCGGCAGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGCGAGGCGAAAGGGCAGCACCGGGCCACGCTCGA
CGCCGACCTGGTGCCCGTCCTGGTCGCGCTCGCCGACGACCAGCCGCTGGAACCTCGGCACCGCGACCACGCGCTGACCG
GGGACTGGAAGGATCACCGGGATTGCCACGTCAAGCCCGACCTGGTGCTGATCTACCAGAAGCCCGACGCCGACACGCTG
CGCCTGGTGCGCCTCGGCTCTCACTCCGAACTCGGCTTGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT93758 WP_011114070.1 NZ_CP026268:23564-23827 [Aminobacter sp. MSH1]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT93758 NZ_CP026268:23564-23827 [Aminobacter sp. MSH1]
ATGGCTGCAAACCAGCTCGTACAAACGCGCATCGACGGCGCGATCAAGGAAGAAGCGGCGGCCGTCCTGGCCGCGATGGG
CCTTACCGTGTCCGACGCGGTGCGGCTGCTGCTCACGAAGGTGGCCCAGGACAAGGCGCTGCCCTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCCCGCAAGGGCAAGCTGCCGCGCTTCGCCACCGTCAACGATCTGATG
GCCGATCTGCATGCGGCAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References